JAK1

Protein JAK1

Identifiers
Janus kinase 1
HUGO:JAK1 hgnc_id:HGNC:6190 HGNC:6190 ENTREZ:3716 UNIPROT:P23458
HUGO:JNK1 HGNC:6190 ENTREZ:3716 UNIPROT:P23458
HUGO:JAK1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / MITOCHONDRIA_OXIDATIVE_STRESS

References
MODULE:CAF
MODULE:INFLAMMATORY_SIGNALING_PATHWAYS
MODULE:CAF_INHIBITION_ANTITUMOR
CASCADE:IL6
CASCADE:PLAU
CASCADE:LIF
CASCADE:IFNG
PMID:21840487
CAF-dependent matrix remodelling is essential for collective carcinoma cell invasion
JAK kinase inhibitor P6 tested blocked remodelling (Hooper et al., 2010). P6 inhibits multiple members of the JAK family (Pedranzini et al., 2006), so we used JAK isoform-specific inhibitors to probe which JAKs are involved; neither JAK2 nor JAK3-specific inhibitors recapitulated the effect of the pan-JAK inhibitor (P6) on matrix remodelling (Figure 1A), suggesting that JAKI is the family member involved.
Jak 1 regulates Actomyosin Contractility in CAFs downstream of GP130-IL6ST IL6 and oncostatin M (OSM) and via STAT3
MACROPHAGE
DENDRITIC_CELL
MODULE:INPUT_INHIBITORS
MODULE:IMMUNE_SUPPRESSION
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
CASCADE:IL10
CASCADE:IL4
CASCADE:IL13
CASCADE:GSF3
MODULE:INPUT_ACTIVATORS
MODULE:IMMUNE_STIMULATION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
NATURAL_KILLER
CASCADE:IL15
CASCADE:IL21
CASCADE:IL2
CASCADE:IFNAB
???21115385
???JAK1 is a member of the Janus kinase family.
???The binding of IL-10 to its receptor activates two members of the Janus kinase family: Jak1 (associated with the IL-1OR1 and
Tyk2 (associated with the IL-10R2)
PMID:19833085
IFNG receptor is assosiated with kinases JAK1 and JAK2
PMID:7512720, PMID:7521688
Jak1 and Jak2 are activated by the G-CSFR

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

JAK1@INNATE_IMMUNE_CELL_Cytosol
JAK1|pho@INNATE_IMMUNE_CELL_Cytosol

Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane

Participates in reactions:
As Reactant or Product:

As Catalyser: