Catalysis

1. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane
2. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane

Inhibition

1. SOCS1@INNATE_IMMUNE_CELL_Cytosol

References
PMID:23124025
Tyk2 IS required for Stat6 (TYR641) activation in monocytes stimulated with IL-13.
PMID:12223527
Stat proteins 1 alpha, 3, 5A, 5B, and 6 are phosphorylated in response to IL-13.
IL-4, in contrast to IL-13, induced very low levels of phosphorylation of Stats 1 and 5 and a more robust phosphorylation of Stat3 and Stat6.
Jak1 is required for Stat6 (TYR641) activation in monocytes stimulated with IL-4
PMID:10485906
SOCS1 inhibits STAT6 activation downstream of IFNG and downregulates IL4 signaling pathway.
PMID:21469115
PI3K signaling is involved in STAT6 activation.