IL2RG:IL4:IL4R:JAK1:JAK2:JAK3

Complex IL2RG:IL4:IL4R:JAK1:JAK2:JAK3

Complex composition:

IL2RG:IL4:IL4R:JAK1|pho:JAK2:JAK3@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:IL2RG:IL4:IL4R:JAK1:JAK2:JAK3

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
MACROPHAGE
MDSC
CASCADE:IL4

IL2RG:IL4:IL4R:JAK1|pho:JAK2:JAK3@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:IL2RG:IL4:IL4R:JAK1:JAK2:JAK3

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
PMID:23124025, PMID:20856220
In human monocytes, IL-4 mediates its effect through the
type I IL-4R, composed of the IL-4R????and common gamma-chain (IL-2R??);
And, probably through type II IL-4Ris composed of the
IL-4Ra chain and IL-13Ra1
PMID:20510870
Type I IL-4 receptors is assosiated with Jak1,JAK2 and JAK3. IL-4Ra associates with JAK1, JAK2 and gammaC with JAK3.
PMID:23124025
IL4 binding induces Jak1 phosphorylation (but not Jak2, JAK3, or TYK2).
in_re446( Innate Immunity ):
Tyk2 IS required for Stat6 (TYR641) activation in monocytes stimulated with IL-13.
PMID:12223527
Stat proteins 1 alpha, 3, 5A, 5B, and 6 are phosphorylated in response to IL-13.
IL-4, in contrast to IL-13, induced very low levels of phosphorylation of Stats 1 and 5 and a more robust phosphorylation of Stat3 and Stat6.
Jak1 is required for Stat6 (TYR641) activation in monocytes stimulated with IL-4
PMID:10485906
SOCS1 inhibits STAT6 activation downstream of IFNG and downregulates IL4 signaling pathway.
PMID:21469115
PI3K signaling is involved in STAT6 activation.
in_re558( Innate Immunity ):
PMID:17485448
Inhibition of??? ???NFkB signaling downstream of??? ???ABIN3??? ???
inhibits expression of??? ???IL8,??? ???IL6,??? ???TNF,??? ???IL12
PMID:16413922
NFKBID (IkBNS) inhibit late phase (after 3h) of expression of proinflanotory cytokines
Il-12p40 (IL-12p40), Il-18 (IL-18) and Csf3 (G_CSF).
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
PMID:17404308
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.
CSF2 upregulates expression of TNF, and have positive influence on IL12p70 (p40+p35), IL23 (p40+p19) expression, probably via induction rapid IkBa degradetion, RELA nuclear translocation and formation p65/p50 heterodimers provided induction of NFkB signaling.
PMID:23390297
MIF inhitits expression of M1 markers such as IL12p40
in_re1115( Innate Immunity ):
IL4 induces expression of TIMP3 via JAK1 pathway

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane

Participates in reactions:
As Reactant or Product:

As Catalyser: