Protein IRS2 map

Identifiers
HUGO:IRS2
insulin receptor substrate 2
HUGO:IRS2 HGNC:6126 ENTREZ:8660 UNIPROT:Q9Y4H2 GENECARDS:IRS2 REACTOME:57529 KEGG:8660 ATLASONC:GC_IRS2 WIKI:IRS2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
PMID:9535722
IL13 induces phosporylation of IRS2 and PLCG1 which is probably a PLC responsible for downstream IL13 dependent Ca2+??mobilization signaling and assosiation of IRS2 and PLCG1
PMID:7890616
PCL (probably PCLG1) induces t hydrolysis of phosphoinositides and activates InsP3-induced intracellular Ca2+??release downstream of IL13.
PMID:19109239
IL4 induces he tyrosine phosphorylation of IRS-2 via Type I IL-4 Receptors.
Activated IRS2 interacts with Grb2 and activates downstrean PI3K signalin.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IRS2@INNATE_IMMUNE_CELL_Cytosol map
  2. IRS2|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. IRS2@INNATE_IMMUNE_CELL_Cytosol map → map IRS2|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. GRB2@INNATE_IMMUNE_CELL_Cytosol map → map GRB2@INNATE_IMMUNE_CELL_Cytosol map