Identifiers
Janus kinase 2
HUGO:JAK2 hgnc_id:HGNC:6192 HGNC:6192 ENTREZ:3717 UNIPROT:O60674
HUGO:JNK2 HGNC:6192 ENTREZ:3717 UNIPROT:O60674
HUGO:JAK2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / INFLAMMATORY_SIGNALING_PATHWAYS 
 Cancer Associated Fibroblasts   / CAF_INHIBITION_ANTITUMOR 
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / MITOCHONDRIA_OXIDATIVE_STRESS 
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity   / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS 
 Innate Immunity   / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS 

References
PMID:14610620
JAK2 is a member of the Janus kinase family.
JAK2 associated with IL13RA1 participates in signal transduction.
PMID:19833085
IFNG receptor is assosiated with kinases JAK1 and JAK2
PMID:20406969, PMID:24091328, PMID:11867689
GM-CSF uniquely inhibited signal transducers and activators of transcription (STAT3) and promoted STAT5 activation, probably downstream of JAK2. STAT5ab(null/null) MDSC were rendered sensitive to sunitinib in the presence of GM-CSF in vitro.
PMID:27216177
FAP as a persistent activator of fibroblastic STAT3 through a uPAR-dependent FAK-Src-JAK2 signaling pathway.

1. JAK2@INNATE_IMMUNE_CELL_Cytosol
2. JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol

1. CSF2:​CSF2RA:​CSF2RB:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane
2. CSF3R:​GSF3:​JAK1|​pho:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane
3. IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane
4. IL12*:​IL12RB1:​IL12RB2:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane
5. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane
6. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane
7. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane
8. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane
9. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane
10. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane
11. IL6:​IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane

1. JAK2@INNATE_IMMUNE_CELL_Cytosol → JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol
2. IL2RG:​IL4:​IL4R@INNATE_IMMUNE_CELL_Membrane + JAK3@INNATE_IMMUNE_CELL_Cytosol + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol → IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane
3. IL13RA1:​IL4:​IL4R@INNATE_IMMUNE_CELL_Membrane + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol + TYK2@INNATE_IMMUNE_CELL_Cytosol + JAK2@INNATE_IMMUNE_CELL_Cytosol → IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane
4. IL13:​IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol + JAK1@INNATE_IMMUNE_CELL_Cytosol → IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane
5. IL6:​IL6R:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol → IL6:​IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​Y759_pho@INNATE_IMMUNE_CELL_Membrane
6. CSF3R:​GSF3@INNATE_IMMUNE_CELL_Membrane + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol → CSF3R:​GSF3:​JAK1|​pho:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane
7. IFNG|​hm2@default + IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane + JAK1@INNATE_IMMUNE_CELL_Cytosol + JAK2@INNATE_IMMUNE_CELL_Cytosol → IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane
8. CSF2@default + CSF2RA:​CSF2RB@INNATE_IMMUNE_CELL_Membrane + JAK2@INNATE_IMMUNE_CELL_Cytosol + JAK2@INNATE_IMMUNE_CELL_Cytosol → CSF2:​CSF2RA:​CSF2RB:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane
9. IL4@default + IL2RG:​IL4R@INNATE_IMMUNE_CELL_Membrane + JAK3@INNATE_IMMUNE_CELL_Cytosol + JAK1@INNATE_IMMUNE_CELL_Cytosol + JAK2@INNATE_IMMUNE_CELL_Cytosol → IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane
10. IL4@default + IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane + JAK1@INNATE_IMMUNE_CELL_Cytosol + JAK2@INNATE_IMMUNE_CELL_Cytosol + TYK2@INNATE_IMMUNE_CELL_Cytosol → IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane
11. IL13@default + IL13RA1:​IL4R@INNATE_IMMUNE_CELL_Membrane + JAK2@INNATE_IMMUNE_CELL_Cytosol + JAK1@INNATE_IMMUNE_CELL_Cytosol + TYK2@INNATE_IMMUNE_CELL_Cytosol → IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane
12. IL12*@default + IL12RB1:​IL12RB2@INNATE_IMMUNE_CELL_Membrane + JAK2@INNATE_IMMUNE_CELL_Cytosol + TYK2@INNATE_IMMUNE_CELL_Cytosol → IL12*:​IL12RB1:​IL12RB2:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane

1. TNF@INNATE_IMMUNE_CELL_Cytosol → TNF@default
2. gTIMP3@INNATE_IMMUNE_CELL_Cytosol → rTIMP3@INNATE_IMMUNE_CELL_Cytosol
3. STAT3@INNATE_IMMUNE_CELL_Cytosol → STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
4. IRS2@INNATE_IMMUNE_CELL_Cytosol → IRS2|​pho@INNATE_IMMUNE_CELL_Cytosol
5. STAT1@INNATE_IMMUNE_CELL_Cytosol → STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
6. STAT6@INNATE_IMMUNE_CELL_Cytosol → STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
7. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol → rIL12p40*@INNATE_IMMUNE_CELL_Cytosol
8. gIL23A@INNATE_IMMUNE_CELL_Cytosol → rIL23A@INNATE_IMMUNE_CELL_Cytosol
9. gIL18@INNATE_IMMUNE_CELL_Cytosol → rIL18@INNATE_IMMUNE_CELL_Cytosol
10. gINHBA@INNATE_IMMUNE_CELL_Cytosol → rINHBA@INNATE_IMMUNE_CELL_Cytosol
11. STAT1@INNATE_IMMUNE_CELL_Cytosol → STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
12. STAT6@INNATE_IMMUNE_CELL_Cytosol → STAT6|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
13. STAT5*@INNATE_IMMUNE_CELL_Cytosol → STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol
14. STAT4@INNATE_IMMUNE_CELL_Cytosol → STAT4|​pho@INNATE_IMMUNE_CELL_Cytosol