Identifiers
NAME:IL13:IL13RA1:IL4R:JAK1:JAK2:TYK2
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
References
MACROPHAGE
CASCADE:IL13
Identifiers
NAME:IL13:IL13RA1:IL4R:JAK1:JAK2:TYK2
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
References
PMID:14610620, PMID:12223527
IL13 acts via IL4 receptor type 2, which contains two subunits IL4R and IL13RA1
PMID:14610620, PMID:12223527, PMID:20510870
JAK1 associated with IL4R and JAK2 or TYK associated with IL13RA1 participate in signal transduction; They phosphorylate the second,
third, or fourth tyrosine residues of the IL-4Ra cytoplasmic domain.
PMID:23124025
IL13 signaling aktivates JAK2 and TYK2 not JAK1.
in_re444( Innate Immunity ):
Tyk2 but not Jak2 is involved in regulating the IL-13-stimulated activation of Stat1(TYR701)
PMID:12223527
Stat proteins 1 alpha, 3, 5A, 5B, and 6 are phosphorylated in response to IL-13.
in_re446( Innate Immunity ):
Tyk2 IS required for Stat6 (TYR641) activation in monocytes stimulated with IL-13.
IL-4, in contrast to IL-13, induced very low levels of phosphorylation of Stats 1 and 5 and a more robust phosphorylation of Stat3 and Stat6.
Jak1 is required for Stat6 (TYR641) activation in monocytes stimulated with IL-4
PMID:10485906
SOCS1 inhibits STAT6 activation downstream of IFNG and downregulates IL4 signaling pathway.
PMID:21469115
PI3K signaling is involved in STAT6 activation.
in_re558( Innate Immunity ):
PMID:17485448
Inhibition of??? ???NFkB signaling downstream of??? ???ABIN3??? ???
inhibits expression of??? ???IL8,??? ???IL6,??? ???TNF,??? ???IL12
PMID:16413922
NFKBID (IkBNS) inhibit late phase (after 3h) of expression of proinflanotory cytokines
Il-12p40 (IL-12p40), Il-18 (IL-18) and Csf3 (G_CSF).
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
PMID:17404308
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.
CSF2 upregulates expression of TNF, and have positive influence on IL12p70 (p40+p35), IL23 (p40+p19) expression, probably via induction rapid IkBa degradetion, RELA nuclear translocation and formation p65/p50 heterodimers provided induction of NFkB signaling.
PMID:23390297
MIF inhitits expression of M1 markers such as IL12p40
+ JAK2|pho@INNATE_IMMUNE_CELL_Cytosol + TYK2|pho@INNATE_IMMUNE_CELL_Cytosol + JAK1@INNATE_IMMUNE_CELL_Cytosol → IL13:IL13RA1|pho:IL4R|pho:JAK1:JAK2|pho:TYK2|pho@INNATE_IMMUNE_CELL_Membrane
+ IL13RA1:IL4R@INNATE_IMMUNE_CELL_Membrane + JAK2@INNATE_IMMUNE_CELL_Cytosol + JAK1@INNATE_IMMUNE_CELL_Cytosol + TYK2@INNATE_IMMUNE_CELL_Cytosol → IL13:IL13RA1|pho:IL4R|pho:JAK1:JAK2|pho:TYK2|pho@INNATE_IMMUNE_CELL_Membrane
→ STAT3|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ STAT1|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ STAT6|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ rIL12p40*@INNATE_IMMUNE_CELL_Cytosol
→ rIL23A@INNATE_IMMUNE_CELL_Cytosol
→ rIL18@INNATE_IMMUNE_CELL_Cytosol
→ rINHBA@INNATE_IMMUNE_CELL_Cytosol
→ STAT6|pho|active@INNATE_IMMUNE_CELL_Cytosol