Reaction transcription in_re580 map

gIL23A@INNATE_IMMUNE_CELL_Cytosol map → rIL23A@INNATE_IMMUNE_CELL_Cytosol map

Reaction regulators:
Catalysis
  1. IRF5@INNATE_IMMUNE_CELL_Cytosol map
  2. NFkB*@INNATE_IMMUNE_CELL_Cytosol map
  3. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
Inhibition
  1. IL2RG:​IL4:​IL4R:​JAK1|​pho:​JAK2:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  2. IL13:​IL13RA1|​pho:​IL4R|​pho:​JAK1:​JAK2|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  3. IL13RA1:​IL4:​IL4R:​JAK1|​pho:​JAK2:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  4. NFKB1_p50*|​hm2@INNATE_IMMUNE_CELL_Cytosol map


References
PMID:17404308
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.
CSF2 upregulates expression of TNF, and have positive influence on IL12p70 (p40+p35), IL23 (p40+p19) expression, probably via induction rapid IkBa degradetion, RELA nuclear translocation and formation p65/p50 heterodimers provided induction of NFkB signaling.