Identifiers
NAME:IL13RA1:IL4:IL4R:JAK1:JAK2:TYK2
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
References
MACROPHAGE
MDSC
CASCADE:IL4
Identifiers
NAME:IL13RA1:IL4:IL4R:JAK1:JAK2:TYK2
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
References
PMID:23124025, PMID:20856220
In human monocytes, IL-4 mediates its effect through the
type I IL-4R, composed of the IL-4R????and common gamma-chain (IL-2R??);
And, probably through type II IL-4Ris composed of the
IL-4Ra chain and IL-13Ra1
PMID:12223527
Type II IL-4 receptors associates with Jak1,JAK2 and TYK2
PMID:23124025
IL4 binding induces Jak1 phosphorylation (but not Jak2, JAK3, or TYK2).
in_re558( Innate Immunity ):
PMID:17485448
Inhibition of??? ???NFkB signaling downstream of??? ???ABIN3??? ???
inhibits expression of??? ???IL8,??? ???IL6,??? ???TNF,??? ???IL12
PMID:16413922
NFKBID (IkBNS) inhibit late phase (after 3h) of expression of proinflanotory cytokines
Il-12p40 (IL-12p40), Il-18 (IL-18) and Csf3 (G_CSF).
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
PMID:17404308
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.
CSF2 upregulates expression of TNF, and have positive influence on IL12p70 (p40+p35), IL23 (p40+p19) expression, probably via induction rapid IkBa degradetion, RELA nuclear translocation and formation p65/p50 heterodimers provided induction of NFkB signaling.
PMID:23390297
MIF inhitits expression of M1 markers such as IL12p40
in_re1115( Innate Immunity ):
IL4 induces expression of TIMP3 via JAK1 pathway
+ JAK1|pho@INNATE_IMMUNE_CELL_Cytosol + TYK2@INNATE_IMMUNE_CELL_Cytosol + JAK2@INNATE_IMMUNE_CELL_Cytosol → IL13RA1:IL4:IL4R:JAK1|pho:JAK2:TYK2@INNATE_IMMUNE_CELL_Membrane
+ IL13RA1:IL4R@INNATE_IMMUNE_CELL_Membrane + JAK1@INNATE_IMMUNE_CELL_Cytosol + JAK2@INNATE_IMMUNE_CELL_Cytosol + TYK2@INNATE_IMMUNE_CELL_Cytosol → IL13RA1:IL4:IL4R:JAK1|pho:JAK2:TYK2@INNATE_IMMUNE_CELL_Membrane
→ rTIMP3@INNATE_IMMUNE_CELL_Cytosol
→ rIL12p40*@INNATE_IMMUNE_CELL_Cytosol
→ rIL23A@INNATE_IMMUNE_CELL_Cytosol
→ rIL18@INNATE_IMMUNE_CELL_Cytosol
→ rINHBA@INNATE_IMMUNE_CELL_Cytosol
→ STAT6|pho|active@INNATE_IMMUNE_CELL_Cytosol