Identifiers
HUGO:IL4
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
References
PMID:11160275 PMID:11371360 PMID:1825141 PMID:2965306 PMID:12818165
PMID:20184663
CAFs may also directly influence the polarization of macrophages toward an M2 phenotype: IL-4, one of the key cytokines driving M2-like polarization of macrophages, was shown to be secreted by CAFs
PMID:12401408
IL4 is assosiated with M2 polarization of macrophages
PMID:23124025, PMID:20856220
In human monocytes, IL-4 mediates its effect through the
type I IL-4R, composed of the IL-4R????and common gamma-chain (IL-2R??);
And, probably through type II IL-4Ris composed of the
IL-4Ra chain and IL-13Ra1
PMID:12496409
Arg1 is up-regulated in MDSC by IL-4.
Arg1 increases superoxide production in myeloid cells through a pathway that likely utilizes the reductase domain of inducible NO synthase (iNOS), and that superoxide is required for Arg1-dependent suppression of T cell function.
PMID:18250477
LIL-4 or IL-13 stimulated the release of galectin-3
into the culture media in both BMDMs and PBMs.
PMID:11870632, PMID:9834059
Stimulation of??NK??cells??with IL-4 inhibited IFN-gamma, but increased IL5, IL-13 production.
NK cells stimuletad by IL4 have NK2 subtype ()
References
in_re719( Innate Immunity ):
PMID:12433365, PMID:10485906
INFG induces SOCS1 expression in macrophages.
PMID:10820262
Probably IFNG induces SOCS1 expressiov via IRF1 upregulation downstream of STAT1
PMID:21097505
IL13 induces SOCS1 expression.
+ IL2RG:IL4R@INNATE_IMMUNE_CELL_Membrane → IL2RG:IL4:IL4R@INNATE_IMMUNE_CELL_Membrane
+ IL13RA1:IL4R@INNATE_IMMUNE_CELL_Membrane → IL13RA1:IL4:IL4R@INNATE_IMMUNE_CELL_Membrane
+ JAK3@INNATE_IMMUNE_CELL_Cytosol + JAK1|pho@INNATE_IMMUNE_CELL_Cytosol + JAK2|pho@INNATE_IMMUNE_CELL_Cytosol → IL2RG:IL4:IL4R:JAK1|pho:JAK2:JAK3@INNATE_IMMUNE_CELL_Membrane
+ JAK1|pho@INNATE_IMMUNE_CELL_Cytosol + TYK2@INNATE_IMMUNE_CELL_Cytosol + JAK2@INNATE_IMMUNE_CELL_Cytosol → IL13RA1:IL4:IL4R:JAK1|pho:JAK2:TYK2@INNATE_IMMUNE_CELL_Membrane
→ IL4@default
→ IL4@default
→ IMMUNE_SUPRESSION@default
→ IL4@INNATE_IMMUNE_CELL_Cytosol
+ IL2RG:IL4R@INNATE_IMMUNE_CELL_Membrane + JAK3@INNATE_IMMUNE_CELL_Cytosol + JAK1@INNATE_IMMUNE_CELL_Cytosol + JAK2@INNATE_IMMUNE_CELL_Cytosol → IL2RG:IL4:IL4R:JAK1|pho:JAK2:JAK3@INNATE_IMMUNE_CELL_Membrane
+ IL13RA1:IL4R@INNATE_IMMUNE_CELL_Membrane + JAK1@INNATE_IMMUNE_CELL_Cytosol + JAK2@INNATE_IMMUNE_CELL_Cytosol + TYK2@INNATE_IMMUNE_CELL_Cytosol → IL13RA1:IL4:IL4R:JAK1|pho:JAK2:TYK2@INNATE_IMMUNE_CELL_Membrane
→ JAK1|pho@INNATE_IMMUNE_CELL_Cytosol
→ LGALS3@default
→ rTIMP3@INNATE_IMMUNE_CELL_Cytosol
→ rIL5@INNATE_IMMUNE_CELL_Cytosol
→ CSF1R@INNATE_IMMUNE_CELL_Membrane
→ rSOCS2@INNATE_IMMUNE_CELL_Cytosol
→ CSF2RA@INNATE_IMMUNE_CELL_Membrane
→ CSF1@default
→ SHIP1*@INNATE_IMMUNE_CELL_Cytosol
→ STAT3|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ IRS2|pho@INNATE_IMMUNE_CELL_Cytosol
→ STAT6|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ rMAF@INNATE_IMMUNE_CELL_Cytosol
→ gp130*|Y759_pho@INNATE_IMMUNE_CELL_Membrane
→ rIL12p40*@INNATE_IMMUNE_CELL_Cytosol
→ rIL23A@INNATE_IMMUNE_CELL_Cytosol
→ rIL18@INNATE_IMMUNE_CELL_Cytosol
→ rIL13@INNATE_IMMUNE_CELL_Cytosol
→ rINHBA@INNATE_IMMUNE_CELL_Cytosol
→ rSOCS1@INNATE_IMMUNE_CELL_Cytosol
→ STAT6|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ rIFNG@INNATE_IMMUNE_CELL_Cytosol
→ rHIF1A@INNATE_IMMUNE_CELL_Cytosol