Protein CSF1 map

Identifiers
HUGO:CSF1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
PMID:11306493
IL4 signaling blocks CSF (M-CSF) production in DC induced by tumor cells.
PMID:24669294
SCF1 (M-CSF) is assosiated with M2 phenotype of macrophages

CSF1@default

References
in_re423( Innate Immunity  map ):
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10
PMID:16713974
RNAi-mediated knockdown of CREB, Fos, and Jun expression resulted in diminished TLR2-induced IL-10 production
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.
PMID:17404308
CSF1 upregulates expression of IL10 and CCL2 probably via CSF1R.
PMID:15749884
c-Maf binds to the ???206/???171 region in the IL-10 promoter and upregulates IL10 expression.
in_re569( Innate Immunity  map ):
PMID:17404308, PMI:17404308
CSF1 upregulates expression of CCL2 probably via CSF1R.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CSF1@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. CSF1@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CSF1:​CSF1R@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CSF1:​CSF1R@INNATE_IMMUNE_CELL_Membrane map → map IMMUNE_SUPRESSION@default map
  2. CSF1@INNATE_IMMUNE_CELL_Cytosol map → map CSF1@default map
  3. CSF1@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_SUPRESSION@default map
  4. CSF1@default map + CSF1R@INNATE_IMMUNE_CELL_Membrane map → map CSF1:​CSF1R@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
  2. gCCL2@INNATE_IMMUNE_CELL_Cytosol map → map rCCL2@INNATE_IMMUNE_CELL_Cytosol map