RNA IL10 map

Identifiers
HUGO:IL10

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map

References
PMID:16200688 PMID:15282297
PMID:21115385
IL10 is immunosuppressive cytokine.
PMID:10623821, PMID:10623821
IL10??? ??? expression in macrophages is assosiated
with TAM (M2) phenotype.
PMID:17404308
CSF1 induces IL10 and CCL2 mRNA expression in macrophages
PMID:16424049
IFNG induces INOS and IL10 expression and TGFB secretion in MDSC

rIL10@INNATE_IMMUNE_CELL_Cytosol

References
in_re423( Innate Immunity  map ):
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10
PMID:16713974
RNAi-mediated knockdown of CREB, Fos, and Jun expression resulted in diminished TLR2-induced IL-10 production
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.
PMID:17404308
CSF1 upregulates expression of IL10 and CCL2 probably via CSF1R.
PMID:15749884
c-Maf binds to the ???206/???171 region in the IL-10 promoter and upregulates IL10 expression.
in_re427( Innate Immunity  map ):
Production of IL10 is partially ERK dependent.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rIL10@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
    2. rIL10@INNATE_IMMUNE_CELL_Cytosol map → map IL10@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: