Identifiers
HUGO:IL10

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / TCR_SIGNALING 
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity   / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS 

References
PMID:16200688 PMID:15282297 PMID:26755705 PMID:12818165
PMID:20184663
Production of cytokines, chemokines and growth factors showed a significant increase in TAFs for vascular endothelial growth factor, transforming growth factor-beta1, interleukins (IL-4, IL-10) and tumour necrosis factor alpha.
PMID:21115385
IL10 is immunosuppressive cytokine.
PMID:10623821, PMID:10623821
IL10??? ??? expression in macrophages is assosiated
with TAM (M2) phenotype.
PMID:10542212
IL10??? ??? promotes M2??? ???phenotype of macrophages
trough suppression of??? ???NFkB signaling
and inhibition of synthesis of pro-inflammatory cytokines.
PMID:11875494
IL10 stimulates HO1 expression via MAPK p38 stimulation.
PMID:16713974, PMID:14607900
IL10 and Stat3 mediate feedback inhibition of TLR signaling. TLR2/TLR4 induces
IL10 expression. IL10 inhibits exppression of TNF downstream of TLR.
PMID:16713974
Production of IL10 is partially ERK dependent.
PMID:21191065
regulatory effect of galectin-1 is mediated, in part, through its ability to induce, in an Id3 (inhibitor of DNA binding 3)-dependent manner, the expression of IL-10 in monocytes and MdDCs.
At the same tyme IL10 siglaning also participates in ID3 upregulation via PI3K/AKT pathway
PMID:17404308
CSF1 induces IL10 and CCL2 mRNA expression in macrophages
PMID:9834059
NK cells stimulated by IL12 induces IL10 production.
PMID:11207245
IFNA induces IL10 production in Dcs (negative loop)
PMID:21220452
that IL-10 increased??March1??mRNA by approximately six fold
PMID:15579430
Metastatic Melanoma Secreted IL-10 Down-Regulates CD1(CD1a, CD1b, CD1c, and CD1d) protein Molecules on Dendritic Cells in Metastatic Tumor Lesions (
PMID:16424049
IFNG induces INOS and IL10 expression and TGFB secretion in MDSC

References
in_re428( Innate Immunity  ):
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10
in_re424( Innate Immunity  ):
PMID:21115385, PMID:10433356
IL10??? ???acts via IL10??? ???receptor.
IL10??? ???first binds to IL10RA
The IL10/IL10R1A ???interaction changes the cytokine
conformation allowing the association of
the IL10/IL10RA ???complex with IL10RB.
PMID:???15833879
???Anti IL-10 receptor???specific antibody
switched TAMs from an M2 to an M1
macrophage???like phenotype.
in_re470( Innate Immunity  ):
PMID:12193690
IL-10 induces arginase-2 expression
in_re898( Innate Immunity  ):
PMID:15749903
NFKBID (IkBNS) expression is induced by IL-10.
in_re900( Innate Immunity  ):
PMID:17485448
IL10??? ???upregulates expression of??? ???TNIP3 (ABIN3).
in_re930( Innate Immunity  ):
PMID:11875494
IL10-induced p38 phosphorylation.
PMID:20435894
SHIP inhibit MAPKp38 activation and prevent
MKNK1 phosphorylation by inhibiting the p38MAPK
pathway downstream of IL10.
PMID:10925299
IL13 induces p38 MAPK phosphorilation and activation, p38 MAPK participates in arginase activation??downstream of IL13.
PMID:23508573
HMGB1 induces activation (phosphorylation) of p38 via TLR4.
PMID:12811837, PMID:16713974
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
PMID:16713974
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling.
PMID:11438547, PMID:24378531
Both TNFR1 and TNFR2 signaling pathways are needed for activation of p38 MAPK.
in_re1117( Innate Immunity  ):
PMID:23124025
IL13 induces DUSP1 expression via TYK2 and probably STAT6

References
in_re427( Innate Immunity  ):
PMID:16713974
Production of IL10 is partially ERK dependent.
in_re428( Innate Immunity  ):
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10

1. IL10@INNATE_IMMUNE_CELL_Cytosol

1. IL10@default

1. IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane
2. IL10:​IL10RA|​Y446_pho|​Y496_pho:​IL10RB:​JAK1|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane

1. IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol → IL10:​IL10RA|​Y446_pho|​Y496_pho:​IL10RB:​JAK1|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane
2. IL10@INNATE_IMMUNE_CELL_Cytosol → IMMUNE_SUPRESSION@default
3. IL10@default + IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane → IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane
4. rIL10@INNATE_IMMUNE_CELL_Cytosol → IL10@INNATE_IMMUNE_CELL_Cytosol
5. IL10@INNATE_IMMUNE_CELL_Cytosol → IL10@default

1. JAK1@INNATE_IMMUNE_CELL_Cytosol → JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol
2. TYK2@INNATE_IMMUNE_CELL_Cytosol → TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol
3. gID3@INNATE_IMMUNE_CELL_Cytosol → rID3@INNATE_IMMUNE_CELL_Cytosol
4. THBS1@INNATE_IMMUNE_CELL_Cytosol → THBS1@default
5. gCD163@MARKERS_MACROPHAGE → rCD163@MARKERS_MACROPHAGE
6. ICAM1@INNATE_IMMUNE_CELL_Cytosol → ICAM1@INNATE_IMMUNE_CELL_Membrane
7. gMARCH1@INNATE_IMMUNE_CELL_Cytosol → rMARCH1@INNATE_IMMUNE_CELL_Cytosol
8. gDUSP1@INNATE_IMMUNE_CELL_Cytosol → rDUSP1@INNATE_IMMUNE_CELL_Cytosol
9. CD80@INNATE_IMMUNE_CELL_Cytosol → CD80@INNATE_IMMUNE_CELL_Membrane
10. STAT3@INNATE_IMMUNE_CELL_Cytosol → STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
11. gARG2@INNATE_IMMUNE_CELL_Cytosol → rARG2@INNATE_IMMUNE_CELL_Cytosol
12. gMHC class II*@INNATE_IMMUNE_CELL_Cytosol → rMHC class II*@INNATE_IMMUNE_CELL_Cytosol
13. rCD1*@INNATE_IMMUNE_CELL_Cytosol → CD1*@INNATE_IMMUNE_CELL_Cytosol
14. gNFKBID@INNATE_IMMUNE_CELL_Cytosol → rNFKBID@INNATE_IMMUNE_CELL_Cytosol
15. gTNIP3@INNATE_IMMUNE_CELL_Cytosol → rTNIP3@INNATE_IMMUNE_CELL_Cytosol
16. p38*@INNATE_IMMUNE_CELL_Cytosol → p38*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol