Catalysis

1. IL10@default
2. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@INNATE_IMMUNE_CELL_Membrane
3. MAP2K4|​pho@INNATE_IMMUNE_CELL_Cytosol
4. MAP2K3|​pho@INNATE_IMMUNE_CELL_Cytosol
5. FCER1G:​HLA-G:​KIR2DL4|​pho@INNATE_IMMUNE_CELL_Membrane
6. TNF:​TNFR2*:​TRAF1:​TRAF2@INNATE_IMMUNE_CELL_Membrane

Inhibition

1. SHIP1*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
2. DUSP1@INNATE_IMMUNE_CELL_Cytosol
3. IFNG|​hm2@default

References
PMID:11875494
IL10-induced p38 phosphorylation.
PMID:20435894
SHIP inhibit MAPKp38 activation and prevent
MKNK1 phosphorylation by inhibiting the p38MAPK
pathway downstream of IL10.
PMID:10925299
IL13 induces p38 MAPK phosphorilation and activation, p38 MAPK participates in arginase activation??downstream of IL13.
PMID:23508573
HMGB1 induces activation (phosphorylation) of p38 via TLR4.
PMID:12811837, PMID:16713974
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
PMID:16713974
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling.
PMID:11438547, PMID:24378531
Both TNFR1 and TNFR2 signaling pathways are needed for activation of p38 MAPK.