Identifiers
HUGO:MAP2K3
mitogen-activated protein kinase kinase 3
HUGO:MAP2K3 HGNC:6843 ENTREZ:5606 UNIPROT:P46734
PRKMK3
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
PMID:24104473 PMID:16799472 PMID:11371360 PMID:15735649
synonym:MKK3 synonym:MEK3
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
CASCADE:TLR2_4
PMID:10661401
MKK3 is activated by ??1 Integrin Cross-Linking on Human NK Cells,
It activates p38MAPK regulated IL8 production by NK cells downstream of integrin signaling.
PMID:9379049
MKK3 and MKK4 are capable of phosphorylating p38mapk in macrophages,
downstream of TNF/Tnf receptor signaling.
MAP2K for P38 pathway. MEK3 is more strongly activated by physical and chemical stresses than by other stimuli.
PMID:11274345
References
in_re930( Innate Immunity ):
PMID:11875494
IL10-induced p38 phosphorylation.
PMID:20435894
SHIP inhibit MAPKp38 activation and prevent
MKNK1 phosphorylation by inhibiting the p38MAPK
pathway downstream of IL10.
PMID:10925299
IL13 induces p38 MAPK phosphorilation and activation, p38 MAPK participates in arginase activation??downstream of IL13.
PMID:23508573
HMGB1 induces activation (phosphorylation) of p38 via TLR4.
PMID:12811837, PMID:16713974
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
PMID:16713974
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling.
PMID:11438547, PMID:24378531
Both TNFR1 and TNFR2 signaling pathways are needed for activation of p38 MAPK.