Identifiers
HUGO:CD80
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / SMAC
Adaptive Immune Response / INHIBITING_CHECKPOINTS
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CAF_INHIBITION_ANTITUMOR
Innate Immunity / MARKERS_DC
References
PMID:15197224, PMID:7523569, PMID:9359474
The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation.
PMID:22437870; PMID:12810107
CD80 and CD86 act lic coactivators of T-cells when they interact with CD28 and
inhibit T-cells via interactions with CTLA4
PMID:18585785, PMID:17629517
human B7-1(CD80) can interact with human PD-L1 with affinity greater than that of B7-1 with CD28, but less than that of B7-1 with CTLA-4 or of PD-L1 with PD-1.
ligation of PD-L1 on T cells by B7-1 inhibits T cell responses in mouse T-cells
PMID:26405600
CAFs express MHC class II but do not provide costimulation through CD80 as normal fibroblasts
PMID:25582338
The expression levels of CD80 and CD83, the molecules involved in T-cell activation, was similar between the two DC subsets (IL4 and IL15)
PMID:11964292, PMID:14764699
IFNAR signaling upregulates surface expression of CD80, CD86, CD40.Probably via STAT1
PMID:22437870
PMID:25215878
FLT3 ligand upregulates surface expression of CD80 in DCs.
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD23
??15034038
IL3 induces CD80, CD86, CD40 surface expression in pDC
PMID:7512027
IL-10 inhibits surface expression CD80 (B7) on monocytes, even following induction of these molecules by IL4 or IFNG and diminishes the antigen-presenting capacity of monocytes.
PMID:20231889
Dcs Stat5-Tg mice are expressing ot surface high levels of MHC-II and costimulatory molecules such as CD80, CD86 and CD54 (ICAM1) and have increased level of I12 secretion (.)
Expression of CD83, a and CD80 and was significantly enhanced by the FLT3L
??11207245
I IFN receptor signaling regulates antigen cross-presentation to CD8(+) T cells. (), probably via upregulation of CD80, CD86, CD40, CD83 and MHC class II and CD11c,
PMID:17513775
Probably via STAT1(demondrtated for CD40 and CD11c PMID:14764699, and for CD40, CD80, CD86, and MHC II?? )
INFG up-regulates ICAM1 and CD80 (B7) surface expression in monocytes. And IL10 inhibit it.
+ CD86@INNATE_IMMUNE_CELL_Membrane → CD80:CD86@INNATE_IMMUNE_CELL_Membrane
→ CD80@INNATE_IMMUNE_CELL_Membrane
→ Immune_checkpoints_T_cells_Activators@default
→ Antigen_presentation@default