Protein CD86 map

Identifiers
HUGO:CD86

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / SMAC  map
 Innate Immunity  map  / MARKERS_DC  map

References
PMID:15197224, PMID:7523569, PMID:9359474
The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation.
PMID:22437870;PMID:12810107
CD80 and CD86 act lic coactivators of T-cells when they interact with CD28 and
inhibit T-cells via interactions with CTLA4
PMID:20805416
Expression of CD86, a critical costimulatory molecule for efficient T cell priming, is enhanced in activated MDSC during mTOR inhibition
This phenotype was not observed in moDCs, in which surface expression of CD80 and CD86 was inhibited by rapamycin.
PMID:11964292, PMID:14764699
IFNAR signaling upregulates surface expression of CD80, CD86, CD40.Probably via STAT1
PMID:22437870
PMID:10477595, PMID:8920882, PMID:??25215878
FLT3L induces Ag-presenting ability of Dcs. Probably via induction of surface expression of class II MHC and CD86.
PMID:22076556, PMID:21220452 , PMID:24218453
CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD23
PMID:??15034038
IL3 induces CD80, CD86, CD40 surface expression in pDC
PMID:9359474
DC derived from progressing metastases do not express CD86, probably its expression is inhibited by IL10 released by melanoma cells, such cells induce T-cell anergy.(DC derived from progressing metastases do not express CD86, probably its expression is inhibited by IL10 released by melanoma cells, such cells induce T-cell anergy.(DC derived from progressing metastases do not express CD86, probably its expression is inhibited by IL10 released by melanoma cells, such cells induce T-cell anergy.
PMID:20231889
Dcs Stat5-Tg mice are expressing ot surface high levels of MHC-II and costimulatory molecules such as CD80, CD86 and CD54 (ICAM1) and have increased level of I12 secretion (.)
PMID:10477595, PMID:8920882, PMID:25215878
PMID:??11207245
I IFN receptor signaling regulates antigen cross-presentation to CD8(+) T cells. (), probably via upregulation of CD80, CD86, CD40, CD83 and MHC class II and CD11c,
PMID:17513775
Probably via STAT1(demondrtated for CD40 and CD11c PMID:14764699, and for CD40, CD80, CD86, and MHC II?? )
PMID:25384214
the stimulatory effect of TANs was partially abrogated in the presence of anti-CD54 and -CD86 blocking Abs

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CD86@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD86@INNATE_IMMUNE_CELL_Membrane map
  2. CD86|​ubi@INNATE_IMMUNE_CELL_Membrane map
In compartment: MARKERS_DC
  1. CD86@MARKERS_DC map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD80:​CD86@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CD86|​ubi@INNATE_IMMUNE_CELL_Membrane map → map degraded
  2. CD80@INNATE_IMMUNE_CELL_Membrane map + CD86@INNATE_IMMUNE_CELL_Membrane map → map CD80:​CD86@INNATE_IMMUNE_CELL_Membrane map
  3. CD86@INNATE_IMMUNE_CELL_Cytosol map → map CD86@INNATE_IMMUNE_CELL_Membrane map
  4. CD86@INNATE_IMMUNE_CELL_Membrane map → map Immune_checkpoints_T_cells_Activators@default map
  5. CD80:​CD86@INNATE_IMMUNE_CELL_Membrane map → map Antigen_presentation@default map
  6. CD86@INNATE_IMMUNE_CELL_Membrane map → map CD86|​ubi@INNATE_IMMUNE_CELL_Membrane map
As Catalyser: