Complex IL10:IL10RA:IL10RB map
Complex composition:

  1. IL10RB map
  2. IL10 map
  3. IL10RA map

IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:IL10:IL10RA:IL10RB

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
PMID:21115385, PMID:10433356
IL10??? ???acts via IL10??? ???receptor.
IL10??? ???first binds to IL10RA
The IL10/IL10R1A ???interaction changes the cytokine
conformation allowing the association of
the IL10/IL10RA ???complex with IL10RB.
PMID:???15833879
???Anti IL-10 receptor???specific antibody
switched TAMs from an M2 to an M1
macrophage???like phenotype.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map IL10:​IL10RA|​Y446_pho|​Y496_pho:​IL10RB:​JAK1|​pho:​TYK2|​pho@INNATE_IMMUNE_CELL_Membrane map
  2. IL10@default map + IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane map → map IL10:​IL10RA:​IL10RB@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. JAK1@INNATE_IMMUNE_CELL_Cytosol map → map JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. TYK2@INNATE_IMMUNE_CELL_Cytosol map → map TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map