Complex IL10:IL10RA:IL10RB:JAK1:TYK2
Complex composition:
- IL10
- IL10RB
- IL10RA
- JAK1
- TYK2
IL10:IL10RA|Y446_pho|Y496_pho:IL10RB:JAK1|pho:TYK2|pho@INNATE_IMMUNE_CELL_Membrane
Identifiers
NAME:IL10:IL10RA:IL10RB:JAK1:TYK2
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity
/ IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
References
PMID:???21115385, PMID:7543512
???The binding of IL-10 to its receptor activates JAK1
Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
- IL10:IL10RA|Y446_pho|Y496_pho:IL10RB:JAK1|pho:TYK2|pho@INNATE_IMMUNE_CELL_Membrane
Participates in reactions:
As Reactant or Product:- IL10:IL10RA:IL10RB@INNATE_IMMUNE_CELL_Membrane
+ JAK1|pho@INNATE_IMMUNE_CELL_Cytosol
+ TYK2|pho@INNATE_IMMUNE_CELL_Cytosol
→
IL10:IL10RA|Y446_pho|Y496_pho:IL10RB:JAK1|pho:TYK2|pho@INNATE_IMMUNE_CELL_Membrane
As Catalyser:- STAT3@INNATE_IMMUNE_CELL_Cytosol
→
STAT3|pho|active@INNATE_IMMUNE_CELL_Cytosol