Gene ID3 map

Identifiers
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
HUGO:ID3, HGNC:5362, ENTREZ:3399, UNIPROT:Q02535, GENECARDS:GC01M023884
HUGO:ID3

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / MIRNA_TF_IMMUNOSUPPRESSIVE  map

References
PMID:11708773
PMID:15252039
ID2 is target of HIF1 upon hypoxic conditions
 MACROPHAGE  map
 MDSC  map
CASCADE:LGALS1
CASCADE:IL10
PMID:21191065
regulatory effect of galectin-1 is mediated, in part, through its ability to induce, in an Id3 (inhibitor of DNA binding 3)-dependent manner, the expression of IL-10 in monocytes and MdDCs.
At the same tyme IL10 siglaning also participates in ID3 upregulation via PI3K/AKT pathway
(autocrine loop)

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gID3@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gID3@INNATE_IMMUNE_CELL_Cytosol map → map rID3@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: