Identifiers
HUGO:HLA-DMA HUGO:HLA-DMB HUGO:HLA-DOA HUGO:HLA-DOB HUGO:HLA-DPA1 HUGO:HLA-DPB1 HUGO:HLA-DQA1 HUGO:HLA-DQA2 HUGO:HLA-DQB1 HUGO:HLA-DQB2 HUGO:HLA-DRA HUGO:HLA-DRB1 HUGO:HLA-DRB3 HUGO:HLA-DRB4 HUGO:HLA-DRB5
References
DENDRITIC_CELL
MACROPHAGE
CASCADE:MIF
CASCADE:IL10
CASCADE:IFNG
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD206, CD23
PMID:22076556, PMID:22076556, PMID:25720354
Like MHC class I molecules, class II molecules are also heterodimers, but in this case consist of two homogenous peptides, an ?? and ?? chain, both of which are encoded in the MHC.
MHC class II molecules present antigen peptides to CD4+ T cells
PMID:7902377, PMID:1655948
IL-10 down-regulates not only the constitutive class 2 MHC expression on mono-
cytes , but also inhibites strongly the IL-13-induced
class 2 MHC expression .
PMID:8871614
IL13 induces MHC classe II expression via STAT6 pathway
CASCADE:CSF2
PMID:??19224634
STAT5 promotes expression of MHC class II transactivator protein (CIITA) and upregulates MHC class II expression downstream of CSF2
PMID:??8624807
IFN-?? has been shown to up-regulate MHC class II expression on dendritic cells.??
Via CIITA.