Protein THBS1 map

Identifiers
HGNC:11785
thrombospondin 1
HUGO:THBS1, HGNC:11785, ENTREZ:7057, UNIPROT:P07996,GENECARDS:GC15P039873
HUGO:THBS1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / ECM  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
PMID:11982756
PMID:8349738
THBS1 cleaves the latent TGFB1 complex, releasing TGFB in its active form
PMID:22943793
 DENDRITIC_CELL  map
CASCADE:THBS1
CASCADE:IL10
CASCADE:TGFB
CASCADE:PGE2
PMID:14996710
Thrombospondin-1 is associated with tumor microenvironment.
PMID:10657674
CD47 engagement by Thrombospondin-1 peptide inhibits cytokine production and maturation of human dendritic cells.
PMID:14568985
Thrombospondin 1 is an autocrine negative regulator of human dendritic cell activation.
The endogenous TSP produced during early DC activation negatively regulates IL-12, TNF-??, and IL-10 release through its interactions with CD47.
IL-10, TGF-??, and PGE2??enhance TSP secretion by Dcs

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. THBS1@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. THBS1@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD36:​THBS1@INNATE_IMMUNE_CELL_Membrane map
  2. CD47:​THBS1@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. THBS1@default map + CD36@INNATE_IMMUNE_CELL_Membrane map → map CD36:​THBS1@INNATE_IMMUNE_CELL_Membrane map
  2. THBS1@INNATE_IMMUNE_CELL_Cytosol map → map THBS1@default map
  3. THBS1@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_SUPRESSION@default map
  4. CD47:​THBS1@INNATE_IMMUNE_CELL_Membrane map → map IMMUNE_SUPRESSION@default map
  5. CD47@INNATE_IMMUNE_CELL_Membrane map + THBS1@default map → map CD47:​THBS1@INNATE_IMMUNE_CELL_Membrane map
As Catalyser: