Protein CD47 map

Identifiers
HUGO:CD47 HGNC:1682
HUGO:CD47

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
PMID:?2015-MOJCSR-02-00015
CASCADE:CD47
 DENDRITIC_CELL  map
CASCADE:THBS1
CASCADE:SIRPA
PMID:11509594
CD47 binds SIRP-?? on DC. SIRP-?? engagement down-regulates DC function
CD47-Fc potently suppressed IL-12 and TNF-?? release by monocyte-derived DC stimulated by SAC. The inhibitory effect was dose dependent, and significant suppression was seen with as little as 10 ng/ml CD47-Fc (Fig. 5???B). Other cytokines, including IL-6 and IL-10, were also suppressed,
CD47-Fc not only suppressed cytokine release by maturing DC, but also largely prevented DC phenotypic maturation. As indicated in Fig. 6???, CD83 and CD86 up-regulation were strongly reduced regardless of the stimulus used. For CD80, the inhibition was almost complete in response to CD40 signaling, moderate in response to SAC, and modest, but significant in response to LPS. CD40 expression was weakly up-regulated during DC maturation. In all three conditions, SIRP-?? ligation by CD47-Fc abrogated the CD40 increase. Note only a slight reduction in HLA-DR expression. All together, these results demonstrate that engagement of SIRP-?? largely inhibits DC maturation.
PMID:10657674, PMID:10657674
CD47 is expresed on dendritic cells
PMID:10657674, PMID:14568985
CD47 engagement by Thrombospondin-1 inhibits cytokine production and maturation of human dendritic cells.
PMID:22310103
CD47 was first identified as a tumor antigen on human ovarian cancer in the 1980s [20]. Since then, CD47 has been found to be expressed on multiple human tumor types
CD47 functions as an inhibitor of phagocytosis through ligation of SIRP?? expressed on phagocytes, leading to tyrosine phosphatase activation and inhibition of myosin accumulation at the submembrane assembly site of the phagocytic synapse [14]. In this way, CD47 serves as a ???don???t eat me signal??? and a marker of self, as loss of CD47 leads to homeostatic phagocytosis of aged or damaged cells

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD47@INNATE_IMMUNE_CELL_Membrane map
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. CD47@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD47:​SIRPA@INNATE_IMMUNE_CELL_Membrane map
  2. CD47:​THBS1@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CD47:​SIRPA@INNATE_IMMUNE_CELL_Membrane map → map EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane map
  2. CD47:​THBS1@INNATE_IMMUNE_CELL_Membrane map → map IMMUNE_SUPRESSION@default map
  3. SIRPA@INNATE_IMMUNE_CELL_Membrane map + CD47@TUMOR_CELL_AS_INDUCTOR_Membrane map → map CD47:​SIRPA@INNATE_IMMUNE_CELL_Membrane map
  4. CD47@INNATE_IMMUNE_CELL_Membrane map + THBS1@default map → map CD47:​THBS1@INNATE_IMMUNE_CELL_Membrane map
  5. KEEP_OUT@TUMOR_CELL_AS_INDUCTOR map → map CD47@TUMOR_CELL_AS_INDUCTOR_Membrane map
As Catalyser: