Identifiers
HUGO:SIRPA
References
CASCADE:SIRPA
NATURAL_KILLER
PMID:11509594
CD47 binds SIRP-?? on DC. SIRP-?? engagement down-regulates DC function
CD47-Fc potently suppressed IL-12 and TNF-?? release by monocyte-derived DC stimulated by SAC. The inhibitory effect was dose dependent, and significant suppression was seen with as little as 10 ng/ml CD47-Fc (Fig. 5???B). Other cytokines, including IL-6 and IL-10, were also suppressed,
CD47-Fc not only suppressed cytokine release by maturing DC, but also largely prevented DC phenotypic maturation. As indicated in Fig. 6???, CD83 and CD86 up-regulation were strongly reduced regardless of the stimulus used. For CD80, the inhibition was almost complete in response to CD40 signaling, moderate in response to SAC, and modest, but significant in response to LPS. CD40 expression was weakly up-regulated during DC maturation. In all three conditions, SIRP-?? ligation by CD47-Fc abrogated the CD40 increase. Note only a slight reduction in HLA-DR expression. All together, these results demonstrate that engagement of SIRP-?? largely inhibits DC maturation
→ EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane
+ CD47@TUMOR_CELL_AS_INDUCTOR_Membrane → CD47:SIRPA@INNATE_IMMUNE_CELL_Membrane