Protein ICAM1 map

Identifiers
HUGO:ICAM1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / SMAC  map
 Innate Immunity  map  / INTEGRINS  map
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map

References
PMID:15356110 PMID:19454690 PMID:14662834 PMID:11592085 PMID:12413632 PMID:1673988 PMID:23364881 PMID:7512027 PMID:20231889 PMID:25384214
 NATURAL_KILLER  map
 DENDRITIC_CELL  map
 MACROPHAGE  map
 NEUTROPHIL  map
CASCADE:IL10
CASCADE:IFNG
CASCADE:IL18
CASCADE:LFA1
PMID:15356110, PMID:19454690
ICAM1 assosiation with LAF-1 provides NK cell cytotoxicity
PMID:14662834
IL-18 up-regulated most strikingly the surface expression of CD54 (ICAM1) and induces F-actin polymerization
PMID:11592085
ICAM-1 regulates the migration of dendritic cells into regional lymph nodes
via polarization of perforin cytotoxic granules. This signaling is
very sensitive to inhibition of actin polymerization by cytochalasin D, of Src family tyrosine kinases by PP1, and was partially sensitive to inhibition of PI3K by wortmannin.
LFA-1-dependent cytotoxicity is sensitive to inhibition by killer cell Ig-like receptors ( CD158a and CD158b).
PMID:12413632
CD18/CD11-ICAM-1 adhesion between effector and target cells plays an
important role in macrophage-mediated tumor cytotox-
icity
PMID:1673988
Both IFN-gamma and TNF induced large increases in the ICAM-1 expression on both cell lines and increased the susceptibility of the tumor cells to monocyte-mediated killing.
PMID:23364881
Intercellular adhesion molecule-1 (ICAM-1) expression correlates with oral cancer progression and induces macrophage/cancer cell adhesion
PMID:7512027
INFG up-regulates ICAM1 and CD80 (B7) surface expression in monocytes. And IL10 inhibit it.
PMID:20231889
Dcs Stat5-Tg mice are expressing ot surface high levels of MHC-II and costimulatory molecules such as CD80, CD86 and CD54 (ICAM1) and have increased level of I12 secretion (.
PMID:25384214
the stimulatory effect of TANs was partially abrogated in the presence of anti-CD54 and -CD86 blocking Abs

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. ICAM1@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. ICAM1@INNATE_IMMUNE_CELL_Membrane map
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. ICAM1@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. ICAM1@INNATE_IMMUNE_CELL_Cytosol map → map ICAM1@INNATE_IMMUNE_CELL_Membrane map
    2. ICAM1@INNATE_IMMUNE_CELL_Cytosol map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
    3. ICAM1@INNATE_IMMUNE_CELL_Cytosol map → map ICAM1@INNATE_IMMUNE_CELL_Membrane map
    4. ICAM1@INNATE_IMMUNE_CELL_Membrane map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. CD11b*:​CD18*@INNATE_IMMUNE_CELL_Membrane map → map (CD11b*:​CD18*)|​active@INNATE_IMMUNE_CELL_Membrane map
    2. DNAM1*|​pho@INNATE_IMMUNE_CELL_Membrane map + CD11a*:​CD18*@INNATE_IMMUNE_CELL_Membrane map → map CD11a*:​CD18*:​DNAM1*|​pho@INNATE_IMMUNE_CELL_Membrane map