DNAM1*

Protein DNAM1*

Identifiers
HUGO:CD226

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / INTEGRINS

References
CASCADE:LFA1
NATURAL_KILLER
PMID:16730454, PMID:24343663, PMID:18657862
DNAX accessory molecule-1 (DNAM-1, CD226) isa cell surface molecule capable of enhancing cytolytic activity and cytokine production in NK cells. Its ligands represented by two members of the nectin family: the poliovirus receptor (PVR CD155) and nectin-2 (CD112). Both molecules can be highly expressed in tumor cell lines, including carcinomas, melanomas and neuroblastomas.
DNAM-1 does not associate with any ITAM-bearing molecule but, after receptor crosslinking, its
intracellular domain gets phosphorylated and delivers an intracellular signal. PKC induces phosphorylation of the Ser329 and probably FYN mediates phosphorylation of DNAM-1 at tyrosine residue 322.
PMID:20189481, PMID:22786724
DNAM1 induces VAV1 pathway probably via LCP2 (SLP76) . It demonstrate synergy with 2B4 in activation of vav1 pathway.
DNAM1 signaling stimulate Ca2+??mobilization provably via PLC-GAMMA2 and induces ERK pathway probably via VAV1.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

DNAM1*@INNATE_IMMUNE_CELL_Cytosol

In compartment: INNATE_IMMUNE_CELL_Membrane

DNAM1*@INNATE_IMMUNE_CELL_Membrane
DNAM1*|pho@INNATE_IMMUNE_CELL_Membrane

Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane

Participates in reactions:
As Reactant or Product:

As Catalyser: