Identifiers
Fas ligand (TNF superfamily, member 6)
HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023
HUGO:FASLG
HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 GENECARDS:FASLG REACTOME:66213 KEGG:356 ATLASONC:GC_FASLG WIKI:FASLG
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / PI3K_AKT_MTOR
References
NATURAL_KILLER
DENDRITIC_CELL
CASCADE:NKG2A
CASCADE:Fc_gamma_RIII
CASCADE:2B4
CASCADE:IFNAB
CASCADE:IL18
CASCADE:LFA1
PMID:12967644
IFNA signaling via STAT1 up-regulates gene expression of cytolytic effectors Fas-L in NK cells.
PMID:8892629
IFN-gamma-inducing factor (IL18) up-regulates Fas ligand-mediated cytotoxic activity (via upregulation of FASL expression) of murine natural killer cell clones
PMID:15120186
2B4 and LFA1 signalings upregulates FasL mRNA and surface expression in NK cells.
FasL transcription is inhibited by NKG2A/CD94
PMID:7650486, PMID:9973469, PMID:9374532
NF-AT, migrates to the nucleus and activates transcription of cytokines TNF, ??GM-CSF??, IL-2, ??IL-4. Fas ligand (??FasL??)??and, possibly, IFNG.
PMID:15160330
PMID:20673124