Protein LCP2 map

Identifiers
HUGO:LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
"lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)", SLP76
HUGO:LCP2 HGNC:6529 ENTREZ:3937 UNIPROT:Q13094

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:23620508 PMID:12640133 PMID:24584089 PMID:21536650 PMID:23474202
 NATURAL_KILLER  map
 MAST_CELL  map
CASCADE:2B4
CASCADE:INTEGRIN_A4B1
CASCADE:LFA1
PMID:24343663, PMID:22786724, PMID:20189481
Selective phosphorylation of tyrosine 113 or tyrosine 128 in LCP2 (SLP-76) enabled binding of SLP-76 to Vav1 and induces
downstream of NKG2D and 2B4 receptors and DNAM1.
PMID:9765283
SHP-1 can bind and dephosphorylate LCP2 (SLP-76) in NK cells downstream of KIRs.
PMID:19909365
One of the main components of LAT1-scaffolded signaling complexes formed after Fc??RI
stimulation of Mast Cells is the adapter protein SLP-76

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. LCP2@INNATE_IMMUNE_CELL_Cytosol map
  2. LCP2|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. LCP2@INNATE_IMMUNE_CELL_Cytosol map → map LCP2|​pho@INNATE_IMMUNE_CELL_Cytosol map
    2. LCP2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map LCP2@INNATE_IMMUNE_CELL_Cytosol map
    3. rLCP2@INNATE_IMMUNE_CELL_Cytosol map → map LCP2@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. VAV1@INNATE_IMMUNE_CELL_Cytosol map → map VAV1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map