Identifiers
NAME:CD11a*:CD18*:DNAM1*
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / INTEGRINS
References
MACROPHAGE
NATURAL_KILLER
CASCADE:LFA1
PMID:10591186
LFA1 physically associates with DNAM1 in NK cells.
Phosphorylated by PKC S329 probably plays a critical role in this association.
PMID:12885870, PMID:22786724
LFA1 signaling induces tyrosine phosphorylation of Vav1 via
Src-family kinases but not Syk or ZAP70. Probably it acts via DNAM1 which
can induce selective phosphorylation of SLP-76.
PMID:15113754
LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56+CD8+ natural killer cells.
(ICAM-2) and ICAM-3 promoted LFA-1-directed perforin release, whereas ICAM-1 had little effect.
Identifiers
NAME:CD11a*:CD18*:DNAM1*
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / INTEGRINS
References
MACROPHAGE
NATURAL_KILLER
CASCADE:LFA1
PMID:10591186, PMID:24440149
LFA1 physically associates with DNAM1 in NK cells.
Phosphorylated by PKC S329 probably plays a critical role in this association.
Cross-Linking of LFA-1 induces tyrosine Phosphorylation of DNAM-,FYN probably phosphorylates DNAM1 Y322.
PMID:20189481, PMID:22786724
DNAM1 induces VAV1 pathway probably via LCP2 (SLP76) . It demonstrate synergy with 2B4 in activation of vav1 pathway.
DNAM1 signaling stimulate Ca2+??mobilization provably via PLC-GAMMA2 and induces ERK pathway probably via VAV1.
PMID:12885870, PMID:22786724
LFA1 signaling induces tyrosine phosphorylation of Vav1 via
Src-family kinases but not Syk or ZAP70. Probably it acts via DNAM1 which
can induce selective phosphorylation of SLP-76.
Coengagement of LFA-1 and 2B4 led to an increase in Vav1 phosphorylation, as compared with that obtained by engagement of LFA-1 alone (Fig. 3 A). Therefore, signals through LFA-1 but not 2B4 lead to a phosphorylation of Vav1 which can be enhanced by 2B4 signals