Protein CD18* map

Identifiers
HUGO:ITGB2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / SMAC  map
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map
 Innate Immunity  map  / INTEGRINS  map
 Innate Immunity  map  / DANGER_SIGNAL_PATHWAYS  map

References
PMID:2150484
CASCADE:CR4
CASCADE:CR3
CASCADE:LFA1
CASCADE:IFNG
 NATURAL_KILLER  map
 MACROPHAGE  map
PMID:24343663, PMID:9712030, PMID:10591186
The phosphorylation of Ser329
by PKC was later found to be critical for the association between
DNAM-1 and CD18(LFA-1) in NK cells.17 This association is required
for DNAM-1 signalling.
PMID:19965656
Coengagement of DNAM-1
and CD18 (LFA-)1 by a Drosophila cell line transfected to express CD155 and
intercellular adhesion molecule 1 triggered the IFN-g production by
NK cells, while these ligands alone had no effects, reinforcing the
functional link between DNAM-1 and LFA-1 in driving NK cell
activation.
PMID:19454690
NKG2D ligation leads to increased adhesion and recruitment of beta1 and beta2 integrins to the cytotoxic synapse.
LFA-1 is required for NKG2D-mediated conjugate formation and cytotoxicity.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CD18*@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD18*@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD11a*:​CD18*@INNATE_IMMUNE_CELL_Membrane map
  2. CD11b*:​CD18*@INNATE_IMMUNE_CELL_Membrane map
  3. CD11c*:​CD18*@INNATE_IMMUNE_CELL_Membrane map
  4. (CD11b*:​CD18*)|​active@INNATE_IMMUNE_CELL_Membrane map
  5. CD11c*:​CD18*:​iC3b*@INNATE_IMMUNE_CELL_Membrane map
  6. CD11a*:​CD18*:​DNAM1*|​pho@INNATE_IMMUNE_CELL_Membrane map
  7. CD11a*:​CD18*:​DNAM1*|​pho|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CD11c*:​CD18*:​iC3b*@INNATE_IMMUNE_CELL_Membrane map → map EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane map
  2. CD11b*:​CD18*@INNATE_IMMUNE_CELL_Membrane map → map (CD11b*:​CD18*)|​active@INNATE_IMMUNE_CELL_Membrane map
  3. (CD11b*:​CD18*)|​active@INNATE_IMMUNE_CELL_Membrane map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
  4. (CD11b*:​CD18*)|​active@INNATE_IMMUNE_CELL_Membrane map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
  5. CD18*@INNATE_IMMUNE_CELL_Cytosol map → map CD18*@INNATE_IMMUNE_CELL_Membrane map
  6. DNAM1*|​pho@INNATE_IMMUNE_CELL_Membrane map + CD11a*:​CD18*@INNATE_IMMUNE_CELL_Membrane map → map CD11a*:​CD18*:​DNAM1*|​pho@INNATE_IMMUNE_CELL_Membrane map
  7. CD11a*:​CD18*:​DNAM1*|​pho@INNATE_IMMUNE_CELL_Membrane map → map CD11a*:​CD18*:​DNAM1*|​pho|​pho@INNATE_IMMUNE_CELL_Membrane map
  8. CD18*@INNATE_IMMUNE_CELL_Membrane map + CD11a*@INNATE_IMMUNE_CELL_Membrane map → map CD11a*:​CD18*@INNATE_IMMUNE_CELL_Membrane map
  9. CD18*@INNATE_IMMUNE_CELL_Membrane map + CD11b*@INNATE_IMMUNE_CELL_Membrane map → map CD11b*:​CD18*@INNATE_IMMUNE_CELL_Membrane map
  10. CD18*@INNATE_IMMUNE_CELL_Membrane map + CD11c*@INNATE_IMMUNE_CELL_Membrane map → map CD11c*:​CD18*@INNATE_IMMUNE_CELL_Membrane map
  11. iC3b*@default map + CD11c*:​CD18*@INNATE_IMMUNE_CELL_Membrane map → map CD11c*:​CD18*:​iC3b*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. ERK1/2*@INNATE_IMMUNE_CELL_Cytosol map → map ERK1/2*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. LCP2@INNATE_IMMUNE_CELL_Cytosol map → map LCP2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. GDP:​RHOA@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map (GTP:​RHOA)|​active@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map
  4. PLD*@INNATE_IMMUNE_CELL_Cytosol map → map PLD*@INNATE_IMMUNE_CELL_Cytosol map
  5. gFASL*@INNATE_IMMUNE_CELL_Cytosol map → map rFASL*@INNATE_IMMUNE_CELL_Cytosol map