Phenotype TUMOR_KILING map
TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR

References
PMID:23510023
RODENT
Recently, in an effort to unravel the regulatory signaling pathways involved in the regulation of mouse bone marrow-derived DC cytotoxic function we have partly deconstructed the molecular machinery controlling iNOS in DC generated with GM-CSF and IL-4 (IL-4 DC) or IL-15 (IL-15 DC). We demonstrated that LPS-induced iNOS expression required the activation of the transcription factors NF-??B and ISGF3 only in IL-15 DC and that distinct signaling pathways such as AP-1 may be required in IL-4 DC. IFN-?? induced iNOS expression in IL-4 DC by a STAT-1 dependent mechanism. However in IL-15 DC, the cooperation of PIAS-1 and STAT-3 prevented iNOS expression in response to IFN-?? stimulation
HUMAN
The mechanisms of cancer cell killing primarily involved the death receptor ligands, perforin/granzyme B and NO.
Recent studies have further highlighted the possibility that human pDC producting type I interferons may also function as tumor cell killers.117 Immature CD4+HLA-DR+Lin??? DC have also been shown to trigger apoptosis of different cancer cells, but not normal cells, by four different TNF family member ligands (TRAIL, TNF, FasL, and Lymphotoxin (LT)-??1??2)
PMID:24777831
Cytotoxic DCs are more efficient than noncytotoxic DCs at activating T cells

Modifications:
In compartment: TUMOR_CELL_AS_EFFECTOR
  1. TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. GZMB@default map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    2. PRF1@default map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    3. HLA-G:​LILRB1@INNATE_IMMUNE_CELL_Membrane map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    4. DAP12*:​KIR3DS1@INNATE_IMMUNE_CELL_Membrane map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    5. (CD11b*:​CD18*)|​active@INNATE_IMMUNE_CELL_Membrane map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    6. NO_production@default map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    7. ROS_production@default map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    8. Granules_exocytosis@INNATE_IMMUNE_CELL_Membrane map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    9. EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    10. GZMK@default map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    11. GZMH@default map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    12. Conjugate_formation@INNATE_IMMUNE_CELL_Membrane map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    13. GZMM@default map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    14. GNLY@default map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    15. GZMA@default map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    As Catalyser: