Protein GZMA map

Identifiers
HUGO:GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HUGO:GZMA HGNC:4708 ENTREZ:3001 UNIPROT:P12544

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

References
PMID:14499263 PMID:8432729
 NATURAL_KILLER  map
CASCADE:IL15
PMID:16106370, PMID:15607806
Five granzymes are expressed in human NK cells (Grz A, B, H, K and M)
GrzA and GrzK are trypsins (cleaving at basic residues arginine and lysine)
GrzB is an aspase, cleaving after aspartic acid residues, and GrzH is a chymase, cleaving after hydrophobic residues such as phenylalanine.
GrzM has a unique enzyme specificity, preferring cleavage after methionine, leucine, or isoleucine.
PMID:11413196, PMID:11413196
VAV1 induces granule exocytosis of granzyme A probably via RAC1-ERK pathway. The absence of Vav1 results in defective granule exocytosis and reduced ability to lyse tumor targets.

Modifications:
In compartment: SECRETORY_GRANULE
  1. GZMA@SECRETORY_GRANULE map
In compartment: default
  1. GZMA@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. GZMA@SECRETORY_GRANULE map → map GZMA@default map
    2. GZMA@default map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    3. rGZMA@INNATE_IMMUNE_CELL_Cytosol map → map GZMA@SECRETORY_GRANULE map
    As Catalyser: