Protein GZMK map

Identifiers
HUGO:GZMK

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map

References
PMID:14499263
 NATURAL_KILLER  map
PMID:16106370, PMID:15607806, PMID:7734049
Five granzymes are expressed in human NK cells (Grz A, B, H, K and M)
GrzA and GrzK are trypsins (cleaving at basic residues arginine and lysine)
GrzB is an aspase, cleaving after aspartic acid residues, and GrzH is a chymase, cleaving after hydrophobic residues such as phenylalanine.
GrzM has a unique enzyme specificity, preferring cleavage after methionine, leucine, or isoleucine.

Modifications:
In compartment: SECRETORY_GRANULE
  1. GZMK@SECRETORY_GRANULE map
In compartment: default
  1. GZMK@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. GZMK@SECRETORY_GRANULE map → map GZMK@default map
    2. GZMK@default map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    As Catalyser: