Protein GZMB map

Identifiers
HUGO:GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HUGO:GZMB HGNC:4709 ENTREZ:3002 UNIPROT:P10144

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
PMID:14499263 PMID:8432729
CASCADE:NKG2D
CASCADE:2B4
CASCADE:IL15
 NATURAL_KILLER  map
PMID:16106370, PMID:15607806
Five granzymes are expressed in human NK cells (Grz A, B, H, K and M)
GrzA and GrzK are trypsins (cleaving at basic residues arginine and lysine)
GrzB is an aspase, cleaving after aspartic acid residues, and GrzH is a chymase, cleaving after hydrophobic residues such as phenylalanine.
GrzM has a unique enzyme specificity, preferring cleavage after methionine, leucine, or isoleucine.
PMID:11062502, PMID:15536084
ERK1/2 activation induces perforin and granzyme B movement towards target tumor cells downstream of PI3K signaling in NK cells.
PMID:20189481
NKG2D, 2B4 signalings induces Granzyme B release probaly via VAV1/ERK pathway
PMID:24795729
PI3K???AKT???mTOR pathway is required for granzyme B production downstream of IL15.
PMID:24248158
Hypoxia-induced autophagy impairs breast cancer cell susceptibility to NK-mediated lysis and that this impairment is reverted by targeting autophagy. We provide evidence that activation of autophagy in hypoxic cells is involved in selective degradation of the pro-apoptotic NK-derived serine protease GZMB/granzyme B, thereby blocking NK-mediated target cell apoptosis. Our in vivo data validate the concept that targeting autophagy in cancer cells promotes tumor regression by facilitating their elimination by NK cells.
PMID:18287025
JNK pathway plays important role in NK activation.JNK induces assosiation of Paxilin with MTOC resulted in polarization of the MTOC and cytolytic granules, and finally exocytosis of cytolytic proteins downstream of NKG2D. Inhibition of JNK activity by D-JNK-1, SP600125, or JNK-1-specific siRNA blocked polarization of granzyme B

Modifications:
In compartment: SECRETORY_GRANULE
  1. GZMB@SECRETORY_GRANULE map
In compartment: default
  1. GZMB@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. GZMB@SECRETORY_GRANULE map → map GZMB@default map
    2. GZMB@default map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
    3. rGZMB@INNATE_IMMUNE_CELL_Cytosol map → map GZMB@SECRETORY_GRANULE map
    As Catalyser: