Identifiers
HUGO:GZMB

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / TCR_SIGNALING 

References
PMID:24795729 PMID:21960590 PMID:22649192
 NATURAL_KILLER 
PMID:24795729
PI3K???AKT???mTOR pathway is required for granzyme B production downstream of IL15
PMID:21960590
Human miR-27a* specifically bound to the 3' untranslated regions of Prf1 and GzmB, down-regulating expression in both resting and activated NK cells.
PMID:22649192
miR-378 and miR-30e suppress IFN-?????upregulated granzyme B and perforin expression in human NK cells
miR-378 and miR-30e are markedly decreased in activated NK cells by IFNA,
miR-378 and miR-30e directly targeted granzyme B and perforin, respectively and suppress of human NK cell cytotoxicity..

1. rGZMB@INNATE_IMMUNE_CELL_Cytosol

1. GZMB:​MIR223@INNATE_IMMUNE_CELL_Cytosol
2. GZMB:​MIR30E@INNATE_IMMUNE_CELL_Cytosol
3. GZMB:​MIR378@INNATE_IMMUNE_CELL_Cytosol
4. GZMB:​MIR27A*@INNATE_IMMUNE_CELL_Cytosol

1. GZMB:​MIR27A*@INNATE_IMMUNE_CELL_Cytosol → degraded
2. arMIR27A*@INNATE_IMMUNE_CELL_Cytosol + rGZMB@INNATE_IMMUNE_CELL_Cytosol → GZMB:​MIR27A*@INNATE_IMMUNE_CELL_Cytosol
3. arMIR378@INNATE_IMMUNE_CELL_Cytosol + rGZMB@INNATE_IMMUNE_CELL_Cytosol → GZMB:​MIR378@INNATE_IMMUNE_CELL_Cytosol
4. gGZMB@INNATE_IMMUNE_CELL_Cytosol → rGZMB@INNATE_IMMUNE_CELL_Cytosol
5. GZMB:​MIR223@INNATE_IMMUNE_CELL_Cytosol → degraded
6. GZMB:​MIR378@INNATE_IMMUNE_CELL_Cytosol → degraded
7. arMIR223@INNATE_IMMUNE_CELL_Cytosol + rGZMB@INNATE_IMMUNE_CELL_Cytosol → GZMB:​MIR223@INNATE_IMMUNE_CELL_Cytosol
8. GZMB:​MIR30E@INNATE_IMMUNE_CELL_Cytosol → degraded
9. arMIR30E@INNATE_IMMUNE_CELL_Cytosol + rGZMB@INNATE_IMMUNE_CELL_Cytosol → GZMB:​MIR30E@INNATE_IMMUNE_CELL_Cytosol
10. rGZMB@INNATE_IMMUNE_CELL_Cytosol → GZMB@SECRETORY_GRANULE