Identifiers
microRNA 223
HUGO:MIR223 HGNC:31603 ENTREZ:407008
HUGO:MIR223
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / MIRNA_TF_IMMUNOSUPPRESSIVE
References
PMID:24272429
PMID:23665507
PMID:23377965
PMID:24206455
PMID:23453900
PMID:21145728
PMID:22902544
PMID:23550650
NATURAL_KILLER
CASCADE:IL15
PMID:20935160
miR-223 was identified as a mature miRNA present in resting NK cells with decreased expression following IL15 activation. miR-223 specifically targets the 3' untranslated region of murine GzmB in vitro, indicating that this miRNA may contribute to control of GzmB translation in resting NK cells.
PMID:21939504
The shuttling of fluorescently-labeled exogenous miRNAs from IL-4-activated macrophages to co-cultivated breast cancer cells without direct cell-cell contact was observed. miR-223, a miRNA specific for IL-4-activated macrophages, was detected within the exosomes released by macrophages and was significantly elevated in the co-cultivated SKBR3 and MDA-MB-231 cells. The invasiveness of the co-cultivated breast cancer cells decreased when the IL-4-activated macrophages were treated with a miR-223 antisense oligonucleotide (ASO) that would inhibit miR-223 expression. Furthermore, results from a functional assay revealed that miR-223 promoted the invasion of breast cancer cells via the Mef2c-??-catenin
→ degraded
→ arMIR223@INNATE_IMMUNE_CELL_Cytosol
+ rGZMB@INNATE_IMMUNE_CELL_Cytosol → GZMB:MIR223@INNATE_IMMUNE_CELL_Cytosol
→ arMIR223@TUMOR_CELL_AS_EFFECTOR