Complex CD11b*:CD18* map
Complex composition:

  1. CD11b* map
  2. CD18* map

CD11b*:​CD18*@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:CD11b*:CD18*

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / INTEGRINS  map
 Innate Immunity  map  / DANGER_SIGNAL_PATHWAYS  map

References
 MACROPHAGE  map
 NATURAL_KILLER  map
CASCADE:CR3
PMID:2060581, PMID:9218574
The CR3(MAC-1) reactive mAb potentiates NK-mediated cytotoxicity
PMID:1358992
Macrophage cytoskeleton association with CR3 and CR4 regulates receptor mobility and phagocytosis of iC3b-opsonized cells.
PMID:8326130
CR3 (CD11b/CD18) pathway induces phagocytosis via PLD activation and mobilization of intracellular Ca2+
PMID:12194823
Rho-kinase and myosin-II control phagocytic cup formation during CR3, but not FcgammaR, phagocytosis.
inhibition of the Rho --> ROK --> myosin-II pathway caused a decreased accumulation of Arp2/3 complex and F-actin around bound particles, which led to a reduction in CR-mediated phagocytic engulfment. FcgammaR-mediated phagocytosis, in contrast, was independent of Rho or ROK activity and was only dependent on myosin-II for particle internalization, not for actin cup formation. While myosins have been previously implicated in FcgammaR phagocytosis, to our knowledge, this is the first demonstration of a role for myosin-II in CR phagocytosis.

(CD11b*:​CD18*)|​active@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:CD11b*:CD18*

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map
 Innate Immunity  map  / INTEGRINS  map
 Innate Immunity  map  / DANGER_SIGNAL_PATHWAYS  map

References
 MACROPHAGE  map
 NATURAL_KILLER  map
CASCADE:CR3
PMID:2060581, PMID:9218574
The CR3(MAC-1) reactive mAb potentiates NK-mediated cytotoxicity
PMID:1358992
Macrophage cytoskeleton association with CR3 and CR4 regulates receptor mobility and phagocytosis of iC3b-opsonized cells.
PMID:8326130
CR3 (CD11b/CD18) pathway induces phagocytosis via PLD activation and mobilization of intracellular Ca2+
PMID:12194823
Rho-kinase and myosin-II control phagocytic cup formation during CR3, but not FcgammaR, phagocytosis.
inhibition of the Rho --> ROK --> myosin-II pathway caused a decreased accumulation of Arp2/3 complex and F-actin around bound particles, which led to a reduction in CR-mediated phagocytic engulfment. FcgammaR-mediated phagocytosis, in contrast, was independent of Rho or ROK activity and was only dependent on myosin-II for particle internalization, not for actin cup formation. While myosins have been previously implicated in FcgammaR phagocytosis, to our knowledge, this is the first demonstration of a role for myosin-II in CR phagocytosis.
PMID:2060581
PMID:12413632
CD18/CD11-ICAM-1 adhesion between effector and target cells plays an
important role in macrophage-mediated tumor cytotox-
icity
PMID:20404138
Inhibition of Mac-1 (CD11b/CD18) reduces myeloid cell recruitment
PMID:1679046
INFG upregulates CD18 surface expression.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD11b*:​CD18*@INNATE_IMMUNE_CELL_Membrane map
  2. (CD11b*:​CD18*)|​active@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CD11b*:​CD18*@INNATE_IMMUNE_CELL_Membrane map → map (CD11b*:​CD18*)|​active@INNATE_IMMUNE_CELL_Membrane map
  2. (CD11b*:​CD18*)|​active@INNATE_IMMUNE_CELL_Membrane map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
  3. (CD11b*:​CD18*)|​active@INNATE_IMMUNE_CELL_Membrane map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
  4. CD18*@INNATE_IMMUNE_CELL_Membrane map + CD11b*@INNATE_IMMUNE_CELL_Membrane map → map CD11b*:​CD18*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. GDP:​RHOA@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map (GTP:​RHOA)|​active@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map
  2. PLD*@INNATE_IMMUNE_CELL_Cytosol map → map PLD*@INNATE_IMMUNE_CELL_Cytosol map