Protein PLD* map

Identifiers
HUGO:PLD1 HUGO:PLD2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
 NATURAL_KILLER  map
 MACROPHAGE  map
 NEUTROPHIL  map
CASCADE:Fc_gamma_RIII
CASCADE:CR1
PMID:7584139, PMID:8326130
CR1 pathway induces phagocytosis via PLD activation and mobilization of intracellular Ca2+.
PMID:15817676
Arf6 couples CD16 to the lipid-modifying enzymes phosphatidylinositol4phosphate 5-kinase type I alpha (PI5KI??) and phospholipase D (PLD) that are involved in the control of granule secretion
PMID:9973479
Beta 1 integrin cross-linking inhibits CD16-induced phospholipase D and secretory phospholipase A2 activity and granule exocytosis in human NK cells.
CD16-stimulated sPLA2 secretion and enzymatic activity are dependent on PLD activation in human NK cells.
PLD-dependent pathway is involved in CD16-mediated NK cell granule exocytosis.
PMID:8326130
CR3 (CD11b/CD18) pathway induces phagocytosis via PLD activation and mobilization of intracellular Ca2+

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PLD*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PLD*@INNATE_IMMUNE_CELL_Cytosol map → map Granules_exocytosis@INNATE_IMMUNE_CELL_Membrane map
    2. PLD*@INNATE_IMMUNE_CELL_Cytosol map → map EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane map
    3. PLD*@INNATE_IMMUNE_CELL_Cytosol map → map PLD*@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. PLA2G2A@INNATE_IMMUNE_CELL_Cytosol map → map PLA2G2A|​pho@INNATE_IMMUNE_CELL_Cytosol map