Protein PLA2G2A map

Identifiers
HUGO:PLA2G2A

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
 NATURAL_KILLER  map
CASCADE:Fc_gamma_RIII
PMID:9973479
BETA1 integrin cross-linking inhibits CD16-induced sPLA2, but not cPLA2 nor PI-PLC, activity in human NK cells.
CD16-stimulated sPLA2 secretion and enzymatic activity are dependent on PLD activation in human NK cells.
PMID:9120268
ERK2 activates Phospholipase A2 group IIA (sPLA2 and cPLA2) by phosphorylation downstream of CD16 activation, but CDl6-induced degranulation in human NK cells is
dependent on ERK activation, but not on sPLA, or cPLA.
PMID:8388321
Arachidonic acid (AA) release via phospholipase A2 (PLA2) activation has positive influence on both NK and ADCC activities of natural killers.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PLA2G2A@INNATE_IMMUNE_CELL_Cytosol map
  2. PLA2G2A|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PLA2G2A@INNATE_IMMUNE_CELL_Cytosol map → map PLA2G2A|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: