Identifiers
HUGO:CD1A HUGO:CD1B HUGO:CD1C HUGO:CD1D
References
DENDRITIC_CELL
CASCADE:IL10
CASCADE:TLR2_4
CASCADE:TNF
PMID:10837075, PMID:10358761, PMID:12391186
CD1 family as nonclassical, Ag-presenting molecules involved in regulation of T cell responses to microbial lipids and glycolipids-containing Ag. Both endogenous and exogenous lipids can be presented, and this pathway may contribute not only to microbial immunity but to autoimmunity and antitumor responses.
In humans, four CD1 proteins (CD1a???d) are expressed by myeloid DCs, whereas in mice only CD1d has been identified. CD1 proteins are functionally heterogeneous, and two subgroups can be identified. Subgroup I, including human CD1b???c, can present glycolipids to a large repertoire of T cells. Indeed, mycobacteria-specific, CD1b-restricted CD8+??/?? TCR T cells have been demonstrated. Binding of the lipids to these CD1 molecules requires endosomal acidification. Subgroup II includes mouse and human CD1d and binds a limited set of Ags (??-galactosyloceramide) and activates a restricted set of T cells as well as NK T cells
PMID:10190903
Alpha-galactosylceramide (alpha-GalCer) exhibits profound antitumor activities in vivo that resemble interleukin (IL)-12-mediated antitumor activities.
Production of IFN-gamma by NKT cells in response to alpha-GalCer required IL-12 produced by dendritic cells (DCs) and direct contact between NKT cells and DCs through CD40/CD40 ligand interactions. Moreover, alpha-GalCer strongly induced the expression of IL-12 receptor on NKT cells from wild-type but not CD1(-/-) or Valpha14(-/-) mice.
PMID:15579430
Metastatic Melanoma Secreted IL-10 Down-Regulates CD1(CD1a, CD1b, CD1c, and CD1d) Molecules on Dendritic Cells in Metastatic Tumor Lesions.
PMID:25582338
CD1a, which is involved in lipid Ag presentation, was significantly lower on imIL-15 DCs and mIL-15 DCs than on IL-4 DCs
PMID:11238627
SB203580, an inhibitor of the p38 MAPK, but not the extracellular signal-regulated kinase l/2 pathway blocker PD98059, inhibited the up-regulation of CD1a, CD40, CD80, CD86, HLA-DR, and the DC maturation marker CD83 induced by LPS and TNF-??.
Metastatic Melanoma Secreted IL-10 Down-Regulates CD1(CD1a, CD1b, CD1c, and CD1d) protein Molecules on Dendritic Cells in Metastatic Tumor Lesions
PMID:11306493
IL4 signaling upregulates CD1a on cell surface of DC cells.
+ B2M@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane + Lipid_antigen@INNATE_IMMUNE_CELL_Cytosol → B2M:CD1*:Lipid_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
→ B2M:CD1*:Lipid_antigen@INNATE_IMMUNE_CELL_Membrane
→ Antigen_presentation@default
→ CD1*@INNATE_IMMUNE_CELL_Cytosol
→ CD1*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane