Reaction transcription in_re423 map

gIL10@INNATE_IMMUNE_CELL_Cytosol map → rIL10@INNATE_IMMUNE_CELL_Cytosol map

Reaction regulators:
Catalysis
  1. MIF@default map
  2. MAF@INNATE_IMMUNE_CELL_Cytosol map
  3. STING*@INNATE_IMMUNE_CELL_Cytosol map
  4. ID3@INNATE_IMMUNE_CELL_Cytosol map
  5. BCL3@INNATE_IMMUNE_CELL_Cytosol map
  6. (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@INNATE_IMMUNE_CELL_Cytosol map
  7. FOS|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  8. CREB1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  9. TGFB*@default map
  10. TRAF3@INNATE_IMMUNE_CELL_Cytosol map
  11. CSF1@default map
  12. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
Inhibition
  1. FLT3LG@default map
  2. IRF5@INNATE_IMMUNE_CELL_Cytosol map
  3. IFNG|​hm2@default map


References
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10
PMID:16713974
RNAi-mediated knockdown of CREB, Fos, and Jun expression resulted in diminished TLR2-induced IL-10 production
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.
PMID:17404308
CSF1 upregulates expression of IL10 and CCL2 probably via CSF1R.
PMID:15749884
c-Maf binds to the ???206/???171 region in the IL-10 promoter and upregulates IL10 expression.