Identifiers
NAME:DEPTOR:MLST8:MTOR:PRAS40*:RPTOR
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
DENDRITIC_CELL
NATURAL_KILLER
PMID:16469695, PMID:26159692
mTOR Complex 1 (mTORC1) is composed of mTOR itself, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8 (MLST8) and the recently identified PRAS40 and DEPTOR
PMID:22504639, PMID:20805416
Impaired mTORC1 signal resulted in the suppression of IL-10 production in DC.
IL-10 expression was impaired at both protein and mRNA levels in RaptorDC???/??? mice.
PMID:19143636
The signalling function of mTOR complex 1 is activated by Rheb-GTP.
PMID:20805416
mTOR pathway plays divergent roles during activation and differentiation of myeloid DCs (MDSC) and monocyte-derived DCs (moDCs). Inhibition of mTORC1 in MDSC activated with TLR-dependent or -independent stimuli increased proinflammatory cytokines and NF-??B, whereas IL-10 and STAT3 were blocked. Rapamycin regulated the costimulatory/surface molecules CD86, programmed death ligand-1, and CD25 on MDSC and significantly increased the T cell allostimulatory potential of MDSC. In contrast, rapamycin suppressed immunostimulatory molecules and the allostimulatory potential of LPS-stimulated moDCs by an inability to augment NF-??B signaling. In differentiating moDCs, the PI3K/Akt-dependent mTOR pathway was constitutively activated by GM-CSF to induce DC differentiation in an mTORC1-dependent manner.
Identifiers
NAME:DEPTOR:MLST8:MTOR:PRAS40*:RPTOR
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
DENDRITIC_CELL
NATURAL_KILLER
CASCADE:IL15
CASCADE:CSF2
PMID:24973821, PMID:24795729
High level of IL15 activates mTOR. mTOR controls production of GZMA and GZMB and IFNG production downstream of IL15
PMID:16469695, PMID:26159692
mTOR Complex 1 (mTORC1) is composed of mTOR itself, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8 (MLST8) and the recently identified PRAS40 and DEPTOR
PMID:22504639, PMID:20805416
Impaired mTORC1 signal resulted in the suppression of IL-10 production in DC.
IL-10 expression was impaired at both protein and mRNA levels in RaptorDC???/??? mice.
PMID:19143636
The signalling function of mTOR complex 1 is activated by Rheb-GTP.
PMID:20805416
mTOR pathway plays divergent roles during activation and differentiation of myeloid DCs (MDSC) and monocyte-derived DCs (moDCs). Inhibition of mTORC1 in MDSC activated with TLR-dependent or -independent stimuli increased proinflammatory cytokines and NF-??B, whereas IL-10 and STAT3 were blocked. Rapamycin regulated the costimulatory/surface molecules CD86, programmed death ligand-1, and CD25 on MDSC and significantly increased the T cell allostimulatory potential of MDSC. In contrast, rapamycin suppressed immunostimulatory molecules and the allostimulatory potential of LPS-stimulated moDCs by an inability to augment NF-??B signaling. In differentiating moDCs, the PI3K/Akt-dependent mTOR pathway was constitutively activated by GM-CSF to induce DC differentiation in an mTORC1-dependent manner.
In differentiating moDCs, the PI3K/Akt-dependent mTOR pathway was constitutively activated by GM-CSF
And this signaling is needful for DC differentiation.
in_re423( Innate Immunity ):
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10
PMID:16713974
RNAi-mediated knockdown of CREB, Fos, and Jun expression resulted in diminished TLR2-induced IL-10 production
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.
PMID:17404308
CSF1 upregulates expression of IL10 and CCL2 probably via CSF1R.
PMID:15749884
c-Maf binds to the ???206/???171 region in the IL-10 promoter and upregulates IL10 expression.