Identifiers
HUGO:MTOR
mechanistic target of rapamycin (serine/threonine kinase)
HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345
HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / FATTY_ACID_BIOSYNTHESIS
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / RCD_GENES
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / PI3K_AKT_MTOR
References
PMID:16469695 PMID:26159692 PMID:23087689
PMID:16469695, PMID:26159692
mTOR Complex 1 (mTORC1) is composed of mTOR itself, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8 (MLST8) and the recently identified PRAS40 and DEPTOR
PMID:21981924
p62 is a key regulator of nutrient sensing in the mTORC1 pathway (data is not from fibroblasts).
PMID:25002027
SQSTM1 (p62) p62 is a suppressor of inflammation and the CAF phenotype in the tumor microenvironment
p62 KO cells displayed reduced mTORC1 activity.
p62 regulates Myc expression via mTOR activation.
synonym:FRAP1
PMID:28216025
DENDRITIC_CELL
NATURAL_KILLER
CASCADE:CSF2
CASCADE:IL15
PMID:25730849
L-10 Mediates ??-Catenin???Dependent Inhibition of Cross-Priming,??-catenin enhanced IL-10 induction through mTOR pathway.
??-Catenin up-regulates level of mTOR in DCs and activates mTOR signaling.
PMID:18492954
mTOR regulates IL-12 expression
through an autocrine action of IL-10 in DC.
PMID:24973821, PMID:24795729
mTOR activity in NK cells is mainly under the control of IL-15.
mTOR deficiency profoundly impaired the early cytokine-driven activation of NK cells at multiple levels.
Inhibition of mTOR abrogates inflammation-induced priming.
mTOR controls the maturation and homeostasis of NK cells.
PI3K???AKT???mTOR pathway is required for granzyme B production downstream of IL15.
mTOR has positive influence on GZMA level in the NK cells.
and NK cells from rapamycin-treated mice (mTOR-inhibition) had attenuated lytic activities toward target tumor cells.
IL15 induces IFNG production via PI3K/AKT/MTOR pathway.
PMID:12906785, PMID:19022819
AKT activates Rapamycin associated protein FRAP2 ( mTOR ) probably through Tuberin/GTP-binding protein Ras homolog enriched in brain ( RHEB ) pathway.
PMID:19568798
PMID:17680028
PMID:21157483