Protein FLT3LG map

Identifiers
HUGO:FLT3LG

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
 DENDRITIC_CELL  map
CASCADE:FLT3LG
PMID:10477595, PMID:9268501, PMID:8920882
The cytokine FLT3 ligand (FL) enhances dendritic cell (DC) generation and differentiation.
PMID:10477595
FL induces Ag-presenting ability of DCs.
FL induced a high level of NF-??B nuclear translocation and specific DNA binding
VEGF inhibited FL-inducible activation of transcription factor NF-??B.
PMID:14670306
STAT3 is required for Flt3L-dependent dendritic cell differentiation.
9176488??
Flt3L treatment not only induced complete tumor regression in a significant proportion of mice, but also decreased tumor growth rate in the remaining mice. Probabli via DC activation.
PMID:16418395
Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development.
PMID:8920882
Daily injection of human Flt3 ligand (Flt3L) into mice results in a dramatic numerical increase in cells co-expressing the characteristic DC markers-class II MHC, CD11c, DEC205, and CD86.
FLT3L induces PU.1 and STAT3 mRNA expression in DC progenitors and downregulates GATA1 mRNA expression.
PMID:25215878
FLT3L partially antagonized IL-10-mediated inhibition on DCs??function and downregulates IL10 mRNA expression in DCs
PMID:10477595, PMID:8920882, ??PMID:25215878
FLT3L induces Ag-presenting ability of Dcs. Probably via induction of surface expression of class II MHC and CD86 and also expression of CD83, a and CD80 and was significantly enhanced by the FLT3L
Daily injection of human Flt3 ligand (Flt3L) into mice results in a dramatic numerical increase in cells co-expressing the characteristic DC markers CD11c, DEC205.

FLT3LG@default

References
in_re423( Innate Immunity  map ):
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10
PMID:16713974
RNAi-mediated knockdown of CREB, Fos, and Jun expression resulted in diminished TLR2-induced IL-10 production
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.
PMID:17404308
CSF1 upregulates expression of IL10 and CCL2 probably via CSF1R.
PMID:15749884
c-Maf binds to the ???206/???171 region in the IL-10 promoter and upregulates IL10 expression.

Modifications:
In compartment: default
  1. FLT3LG@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. FLT3:​FLT3LG@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. FLT3LG@default map + FLT3@INNATE_IMMUNE_CELL_Membrane map → map FLT3:​FLT3LG@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. CD11c*@INNATE_IMMUNE_CELL_Cytosol map → map CD11c*@INNATE_IMMUNE_CELL_Membrane map
  2. rLY75@MARKERS_DC map → map LY75@MARKERS_DC map
  3. rCD11c*@MARKERS_DC map → map CD11c*@MARKERS_DC map
  4. gSTAT3@INNATE_IMMUNE_CELL_Cytosol map → map rSTAT3@INNATE_IMMUNE_CELL_Cytosol map
  5. NFkB*@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map
  6. CD80@INNATE_IMMUNE_CELL_Cytosol map → map CD80@INNATE_IMMUNE_CELL_Membrane map
  7. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
  8. CD83@INNATE_IMMUNE_CELL_Cytosol map → map CD83@INNATE_IMMUNE_CELL_Membrane map
  9. CD74:​MHC_class_II*@Endoplasmic Reticulum_Membrane map → map CD74:​MHC_class_II*@INNATE_IMMUNE_CELL_Membrane map
  10. STAT3@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  11. gFLT3@INNATE_IMMUNE_CELL_Cytosol map → map rFLT3@INNATE_IMMUNE_CELL_Cytosol map
  12. gGATA1@INNATE_IMMUNE_CELL_Cytosol map → map rGATA1@INNATE_IMMUNE_CELL_Cytosol map
  13. gSPI1@INNATE_IMMUNE_CELL_Cytosol map → map rSPI1@INNATE_IMMUNE_CELL_Cytosol map