Protein CD83 map

References
 DENDRITIC_CELL  map
CASCADE:TLR2_4
CASCADE:TNF
CASCADE:FLT3LG
CASCADE:IFNAB
PMID:22076556, PMID:21220452, PMID:24218453
In immature DCs, internalization of MHC class II molecules from the plasma membrane may require the ubiquitin ligase MARCH1, which is controlled by interleukin-10 (IL-10).
CD83 on mature DCs prevents this ubiquitylation of MHC class II molecules and thus stabilizes MHC class II molecules on the cell surface.
Addidionally it prevents CD86 ubiquitinqtion.
PMID:11238627
SB203580, an inhibitor of the p38 MAPK, but not the extracellular signal-regulated kinase l/2 pathway blocker PD98059, inhibited the up-regulation of CD1a, CD40, CD80, CD86, HLA-DR, and the DC maturation marker CD83 induced by LPS and TNF-??.
PMID:25582338
The expression levels of CD80 and CD83, the molecules involved in T-cell activation, was similar between the two DC subsets (IL4 and IL15)
PMID:25215878
FLT3 ligand upregulates surface expression of CD83 in DCs.
PMID:21930769, PMID:21930765, PMID:11964292, PMID:11698286, ??11207245
I IFN receptor signaling regulates antigen cross-presentation to CD8(+) T cells. (), probably via upregulation of CD80, CD86, CD40, CD83 and MHC class II and CD11c.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CD83@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD83@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. CD83@INNATE_IMMUNE_CELL_Cytosol map → map CD83@INNATE_IMMUNE_CELL_Membrane map
    As Catalyser:
    1. MHC_class_II*:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Membrane map → map MHC_class_II*|​ubi:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Cytosol map
    2. CD86@INNATE_IMMUNE_CELL_Membrane map → map CD86|​ubi@INNATE_IMMUNE_CELL_Membrane map