Gene STAT3 map

Identifiers
HUGO:STAT3

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
 MACROPHAGE  map
 MDSC  map
 DENDRITIC_CELL  map
 NEUTROPHIL  map
CASCADE:IL10
CASCADE:FLT3LG
PMID:21383238
Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression.
PMID:16418395
FLT3L induces PU.1 and STAT3 mRNA expression in DC progenitors and downregulates GATA1 mRNA expression. At The same time enforced expression of??STAT3??or??PU.1??in DC progenitors led to the up-regulation of Flt3??mRNA levels, so there is a positive loop in this signaling. ??Enforced??STAT3??or??PU.1??expression instructs progenitors to differentiate into Dcs. Additionaly it induces expression mRNAs of cytokine receptors for G-CSF,??M-CSF, and??GM-CSF probably downstream of STAT3 ()
PMID:20237412
IFN-?? regulates expression of homing and angiogenic factors in neutrophils.
IFNB downregulates expression Cxcr4, Vegf, and Mmp9 in neutrophils
additionally Stat3 and c-myc are downregulated by IFN-??.
(STAT3 is known to be required for full activation of the Cxcr4 gene )

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gSTAT3@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gSTAT3@INNATE_IMMUNE_CELL_Cytosol map → map rSTAT3@INNATE_IMMUNE_CELL_Cytosol map
    2. gSTAT3@INNATE_IMMUNE_CELL_Cytosol map → map rSTAT3@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: