NFkB*

Protein NFkB*

Identifiers
LDOC1, regulator of NFKB signaling
HUGO:LDOC1 hgnc_id:HGNC:6548 HGNC:6548 ENTREZ:23641 UNIPROT:O95751

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS

References
PMID:19302050 PMID:11148124 PMID:25648675 PMID:21411734 PMID:10221648 PMID:11175814
CASCADE:IL1
CASCADE:TNF
PMID:20138012
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-??B-Dependent Manner
Proinflammatory CAFs from a transgenic mouse model of squamous cell carcinoma mediated immune cell recruitment, angiogenesis, and tumor growth. Inhibition of NF-??B signaling abolished these tumor-promoting effects, demonstrating that NF-??B is critical for tumor-enhancing inflammation mediated by CAFs.
Studies using immuno-competent GEM models, demonstrated that normal dermal fibroblasts can be ???educated??? by carcinoma cells to express pro-inflammatory genes, mainly through activation of the NF-???? pathway in the activated fibroblasts. Using PDGFR?? to select normal and tumour derived fibroblasts, the group of Hanahan identified an NF-???? dependent pro-inflammatory gene signature in CAFs isolated from different murine models of cancers originating in the skin, the breast and the pancreas.
NF-????-dependent pro-inflammatory signature included genes such as CXCL1, CXCL2, CXCL5, CCL3 as well as the pro-inflammatory cytokines IL-1?? and IL-6, which, as mentioned above, are all potent chemo-attractants for several immune cell types including, neutrophils, macrophages and other leukocyte populations
PMID:17916596
In vitro analyses
revealed a striking induction of IL-8 expression in CAFs
and LFs by tumor necrosis factor-alpha (TNFA). The effect
of TNFA on CAFs is inhibited by the nuclear factor-kB
inhibitor parthenolide.
PMID:20855962
Hypoxia induces NfkB activation.
pharmacological inactivation of NF??B--another inducer of autophagy-prevents Cav-1 degradation
MDSC
NEUTROPHIL
MACROPHAGE
CASCADE:IL2
CASCADE:IL18
CASCADE:CSF2
CASCADE:FT3LG
CASCADE:IFNG
PMID:10477595
FLT3 induced a high level of NF-??B nuclear translocation and specific DNA binding
VEGF inhibited FT3L-inducible activation of transcription factor NF-??B
PMID:12133954
IL-2R signals can activate a pathway leading to NF-??B p50/p65 activation in NK cells, IL2R signaling induces IkBa degradation and formation of heterodimeric p50/p65 NFkB complexes, NF-??B binds to the upstream enhancer of the perforin gene and that this pathway is involved in the activation of perforin expression (
PMID:20876105, PMID:17027520,
IL18 induces expression of NFKBIZ in NK cells provavly via NFkB pathway or via increasing of mRNA stability..).
PMID:17404308
CSF2 upregulates expression of TNF, and have positive influence on IL12p70 (p40+p35), IL23 (p40+p19) expression, probably via induction rapid IkBa degradation, RELA nuclear translocation and formation p65/p50 heterodimers provided induction of NFkB signaling.
PMID:11399519
STAT1, IRF1 and NF-kB interact with NOS2 promoter and cooperatively activate NOS2 expression in macrophages downstteam of IFNG.
PMID:9864217
IFNG cooperates with TNF and TLR signaling in NF-kB activation.
PMID:18977329
IL-1?? activates MDSC in vitro and in vivo through an IL-1RI/NF-??B pathway.
PMID:21826665
NFkB is activated in TANs

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

NFkB*@INNATE_IMMUNE_CELL_Cytosol

Participates in complexes:

Participates in reactions:
As Reactant or Product:

As Catalyser: