Identifiers
NAME:NFKB1_p50*:RELA
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
PMID:12133954
IL2R signaling induces IkBa degradation and formation of heterodimeric p50/p65 NFkB complexes
NF-??B binds to the upstream enhancer of the perforin gene and that this pathway is involved in the activation of perforin expression downstream of NFkB
PMID:12759422, PMID:10679398
IL-18 induces NF-??B binding to the IFN-?? gene promoter and induction of gene expression. Probably via NIK pathway.
PMID:21224476, PMID:12759422
NFKBIZ binds to the IFNG promoter in response to IL-12 and IL-18 and encreases promoter activity.
NFKBIZ regulates IFNG expression by bindingof NF-??B p65/p50 on IFNG promoter .
in_re878( Innate Immunity ):
PMID:15145317
The activated IKK complex
catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription.
→ NFkB*@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol + IkB*|pho@INNATE_IMMUNE_CELL_Cytosol
→ NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol + p100@INNATE_IMMUNE_CELL_Cytosol