References
PMID:15145317
The activated IKK complex
catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription.