IkB*

Protein IkB*

Identifiers
HUGO:NFKBIA HUGO:NFKBIB HUGO:NFKBIE
NFKB inhibitor alpha
HUGO:NFKBIA hgnc_id:HGNC:7797 HGNC:7797 ENTREZ:4792 UNIPROT:P25963
NFKB inhibitor beta
HUGO:NFKBIB hgnc_id:HGNC:7798 HGNC:7798 ENTREZ:4793 UNIPROT:Q15653
NFKB inhibitor epsilon
HUGO:NFKBIE hgnc_id:HGNC:7799 HGNC:7799 ENTREZ:4794 UNIPROT:O00221

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS

References
PMID:12133805
PMID:23086447, PMID:25305492, PMID:23422957
In canonical NFkB pathway RelB/p50, RelA/p50 and c-Rel/p50 heterodimers are sequestered by I??B-??, I??B-??, and I??B-??
MACROPHAGE
DENDRITIC_CELL
CASCADE:IL13
CASCADE:IL2
CASCADE:CSF2
CASCADE:TNF
PMID:10607713
Maturation of dendritic cells correlates with an increase in I??B??, I??B??, and Bcl-3
PMID:17550372, PMID:9743347
IL13 inhibits NFBB activation via inhibition of p65 nuclear migration in inflammatory macrophages and via prevention of degradation of IkBa (

IkB*|pho@INNATE_IMMUNE_CELL_Cytosol

References
in_re878( Innate Immunity ):
PMID:15145317
The activated IKK complex
catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

IkB*@INNATE_IMMUNE_CELL_Cytosol
IkB*|pho@INNATE_IMMUNE_CELL_Cytosol

Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: