RELB

Protein RELB

Identifiers
HUGO:RELB
RELB proto-oncogene, NF-kB subunit
HUGO:RELB hgnc_id:HGNC:9956 HGNC:9956 ENTREZ:5971 UNIPROT:Q01201

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / ER_STRESS
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS

References
PMID:21873235
CASCADE:IL1
CASCADE:TNF
PMID:18697742
RelB is constitutively expressed in mouse lung fibroblasts.
PMID:10523657
RelB is an important transcription suppressor in fibroblasts which limits the expression of proinflammatory mediators and may exert its function by modulating the stability
Fibroblasts from relb(-/-) mice overexpress interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in response to lipopolysaccharide (LPS) stimulation. These cells have an augmented and prolonged LPS-inducible IKK activity and an accelerated degradation which results in a diminished level of IkappaBalpha protein, despite an upregulated IkappaBalpha mRNA expression.
PMID:23430059
DENDRITIC_CELL
CASCADE:VEGFA
PMID:9881974
RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells.
PMID:2308644
RelB promoted DC activation not as the expected RelB-p52 effector of the noncanonical NF-??B pathway, but as a RelB-p50 dimer regulated by canonical I??Bs, I??B?? and I??B??.
After stimulation with the TLR9 ligand CpG or the TLR2 ligand Pam3CSK4 for 24 h, we indeed observed reduced surface expression of DC activation markers MHCII, CD86, CD80 and CD40 in Relb???/??? DCs (Fig. 5a and Supplementary Fig. 5a,b). Expression of proinflammatory genes, Tnf and Il23a, correlated with the kinetics of CpG or Pam3CSK4-induced RelB activation and were reduced in Relb???/??? DCs (Fig. 5b). In EMSAs, activated RelB-p50 bound to DNA probes containing the ??B sites found in the Tnf and Il23a promoters
Relb transcripts were reduced by ~40% in Rel???/??? relative to wild-type BMDC
PMID:23086447
Alternative NFkB pathway induces via phosphorylation of I??B-specific kinase ?? (IKK-??) the cleavage of p100-RelB to p52-RelB, which then translocates as heterodimer into the nucleus.
Both complete p100 degradation and p100 processing to p52 may occur in Dcs and expression of IKKa, the kinase determining the activity of noncanonical NF-??B pathway, gradually increased during DC differentiation with concomitant p100 processing to p52??
PMID:2649237
In macrophages RELB??/p52 pathway is associated with M1 polarization ()

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

RELB@INNATE_IMMUNE_CELL_Cytosol

Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: